Yttrium chloride hexahydrate

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

08 August 2017 - 05 March 2018

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

flask method

Key result

Water solubility:

1 136 g/L

Conc. based on:

test mat. (dissolved fraction)

Remarks:

yttrium trichloride hexahydrate, calculated based on measured dissolved yttrium concentrations

Loading of aqueous phase:

2 000 g/L

Incubation duration:

>= 24 - <= 72 h

Temp.:

25 °C

pH:

2

Remarks on result:

other: mean of 24, 48 and 72 h

Water solubility:

333 g/L

Conc. based on:

element (dissolved fraction)

Remarks:

yttrium

Loading of aqueous phase:

2 000 g/L

Incubation duration:

>= 24 - <= 72 h

Temp.:

25 °C

pH:

2

Remarks on result:

other: mean of 24, 48 and 72 h

Details on results:

From the preliminary test, the solubility of the test item was determined to be > 1000 g/L (see "Any other information on results incl. tables").
Therefore, it was decided to perform the main test according to the flask method (for results see "Any other information on results incl. tables").

Results were validated by:
- Linearity validation: The analysis showed a good linearity of the method (r > 0.99).
- Accuracy validation: Results in dilution mixture showed a good accuracy which indicates acceptable data (recoveries ranged between 70 and 110%).
- Repeatability validation: The results indicated a good precision of the data (RSD < 20%).
- Specificity: The intensity (CPS) of blank samples measured was negligible.
- Limit of quantification: 125 g Y/L (limit of detection: 25 g Y/L).

Results of the preliminary test with milliQ water at pH 6 or buffer solution at pH 4, 7 or 9 identical results):

Amount of test item weighed (g)	0.1	0.1	0.1	0.1
Volume of water added (mL)	0.1 (pH 6)	0.1 (pH 4)	0.1 (pH 7)	0.1 (pH 9)
Solubility (yes/no)	Yes	Yes	Yes	Yes

Results of the main test:

	Incubation time	Solubility expressed as yttrium content in water (g/L)	Solubility of yttrium trichloride hexahydrate in water*(g/L)	Mean pH measured	Temperature (°C)
Test 1	24h	340	1159	2	25
Test 2	48h	333	1136	2	25
Test 3 (mean of 2 determinations)	72h	327	1115	2	25
Mean	24h, 48h and 72h	333	1136	2	25

* extrapolation using the conversion factor e = Mw YCl3.6H2O / Mw Y = 303.4/88.9 = 3.41

Conclusions:

The mean solubility in water at pH 2 and 25°C is 1136 g/L when expressed as yttrium trichloride hexahydrate and 333 g/L when expressed as yttrium content in water (flask method).

Description of key information

Based on a study performed according to OECD guideline 105 (Jean-Baptiste, 2018; Klimisch 1), the mean solubility of the test item in water is 1136 g/L (yttrium trichloride hexahydrate/L) at pH 2 and 25°C, calculated based on a mean measured dissolved yttrium concentration of 333 g Y/L (flask method).

Key value for chemical safety assessment

Water solubility:

1 136 g/L

at the temperature of:

25 °C