Registration Dossier
Registration Dossier
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EC number: 630-330-6 | CAS number: 21715-46-8
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 6-chloro-N-ethyl-4-methyl-4-phenyl-4H-3,1-benzoxazin-2-amine
- EC Number:
- 630-330-6
- Cas Number:
- 21715-46-8
- Molecular formula:
- C17H18Cl2N2O
- IUPAC Name:
- 6-chloro-N-ethyl-4-methyl-4-phenyl-4H-3,1-benzoxazin-2-amine
- Test material form:
- solid: particulate/powder
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- yes
- Remarks:
- test medium
- Details on test solutions:
- According to the sponsor, the test item was not soluble in the test medium, a special solubilization protocol was carried out before th eexperimentation, according to the OECD 23 guidance document on aquatic toxicity testing of difficult substances and mixtures.
Test organisms
- Test organisms (species):
- Daphnia magna
Study design
- Test type:
- not specified
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
Test conditions
- Test temperature:
- 18 - 22 °C
- pH:
- 6 - 9
- Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
Results and discussion
Effect concentrationsopen allclose all
- Key result
- Duration:
- 24 h
- Dose descriptor:
- EL50
- Effect conc.:
- > 58.3 - < 222.7 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- mobility
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EL50
- Effect conc.:
- > 6.2 - < 10.8 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- mobility
- Details on results:
- All the validity criteria were successful.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The effect of Etofixine on daphnids was performed according to the OECD 202 guideline. In test test conditions, the results obtained are :
- EL50 (24h) = 93.3 mg/L [58.30 - 222.70]
- EL50 (48h) = 8.2 mg/L [6.20 - 10.80] - Executive summary:
The effect of Etofixine on daphnids was performed according to the OECD 202 guideline. In test test conditions, the results obtained are :
- EL50 (24h) = 93.3 mg/L [58.30 - 222.70]
- EL50 (48h) = 8.2 mg/L [6.20 - 10.80]
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