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Administrative data

Description of key information

Based on read-across from DMPT, HIDT is considered not a skin or eye irritant.

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records
Reference
Endpoint:
skin irritation: in vivo
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Justification for type of information:
see attached justification
Reason / purpose:
read-across source
Species:
rabbit
Amount / concentration applied:
0.5 mL
Duration of treatment / exposure:
4 h
Observation period:
14 days
Number of animals:
6
Irritation parameter:
erythema score
Basis:
mean
Time point:
24/48/72 h
Score:
1.72
Max. score:
3
Reversibility:
fully reversible within: Day 14
Irritation parameter:
edema score
Basis:
mean
Time point:
24/48/72 h
Score:
0.22
Max. score:
4
Reversibility:
fully reversible within: Day 10
Irritant / corrosive response data:
see table below
Rabbit # Time [h] Erythema Oedema
1 24 2 0
  48 2 0
  72 2 0
  average 2.0 0.0
2 24 1 0
  48 2 2
  72 1 2
  average 1.3 1.3
3 24 1 0
  48 3 0
  72 2 0
  average 2.0 0.0
4 24 1 0
  48 2 0
  72 1 0
  average 1.3 0.0
5 24 1 0
  48 1 0
  72 1 0
  average 1.0 0.0
6 24 2 0
  48 3 0
  72 3 0
  average 2.7 0.0
Time [h] Erythema Oedema
average 24 1.33 0.00
score 48 2.17 0.33
72 1.67 0.33
24+48+72 1.72 0.22
Interpretation of results:
GHS criteria not met
Conclusions:
Based on read-across from DMPT, DMDS is not considered a skin irritant.
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Link to relevant study records
Reference
Endpoint:
eye irritation: in vivo
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Justification for type of information:
see attached justification
Reason / purpose:
read-across source
GLP compliance:
yes
Species:
rabbit
Strain:
New Zealand White
Amount / concentration applied:
0.1 mL
Duration of treatment / exposure:
Rinsing after 24 h
Observation period (in vivo):
21 days
Number of animals or in vitro replicates:
6 males
Irritation parameter:
cornea opacity score
Basis:
mean
Time point:
24/48/72 h
Score:
0
Max. score:
4
Irritation parameter:
iris score
Basis:
mean
Time point:
24/48/72 h
Score:
0
Max. score:
2
Irritation parameter:
conjunctivae score
Basis:
mean
Time point:
24/48/72 h
Score:
1.56
Max. score:
3
Reversibility:
fully reversible within: Day 10
Irritation parameter:
chemosis score
Basis:
mean
Time point:
24/48/72 h
Score:
0
Max. score:
4
Irritant / corrosive response data:
see table below

Rabbit # Time [h] cornea iris conjunctivae  
        redness chemosis
1 24 0 0 2 0
  48 0 0 2 0
  72 0 0 2 0
  average 0.0 0.0 2.0 0.0
2 24 0 0 3 0
  48 0 0 1 0
  72 0 0 2 0
  average 0.0 0.0 2.0 0.0
3 24 0 0 2 0
  48 0 0 1 0
  72 0 0 2 0
  average 0.0 0.0 1.7 0.0
4 24 0 0 3 0
  48 0 0 1 0
  72 0 0 0 0
  average 0.0 0.0 1.3 0.0
5 24 0 0 1 0
  48 0 0 1 0
  72 0 0 1 0
  average 0.0 0.0 1.0 0.0
6 24 0 0 2 0
  48 0 0 1 0
  72 0 0 1 0
  average 0.0 0.0 1.3 0.0
       
  Time [h] cornea iris conjunctivae  
        redness chemosis
average 24 0.00 0.00 2.17 0.00
score 48 0.00 0.00 1.17 0.00
  72 0.00 0.00 1.33 0.00
  24+48+72 0.00 0.00 1.56 0.00
Interpretation of results:
GHS criteria not met
Conclusions:
Based on read-across from DMPT, DMDS is not considered an eye irritant.
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Justification for classification or non-classification