N-[4-[[(2-amino-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid

Guidance on Safe Use

First-aid measures

Description of first aid measures:

Pay attention to self-protection.

Remove victims from hazardous area. Immediately remove soiled or soaked clothing and remove it to a safe distance. Keep victim warm, in a stabilized position and covered.

Do not leave victims unattended.

If the casualty is unconscious: Place the victim in the recovery position.

Inhalation:

Inhalation is possible if aerosols, mists, dusts, or smoke form.

Move victims into fresh air.

With labored breathing: Provide with oxygen. Consult a doctor.

If the casualty is not breathing: Perform mouth-to-mouth resuscitation, notify emergency physician immediately.

Skin contact:

Wash off affected area immediately with plenty of water for at least 15 minutes.

If symptoms persist, consult a physician for treatment.

Eye contact:

With eye held open, thoroughly rinse immediately with plenty of water for at least 10 minutes.

In case of persistent discomfort: Consult an ophthalmologist.

Ingestion:

Rinse mouth.

Immediately give large quantities of water to drink.

Obtain medical attention.

Most important symptoms and effects, both acute and delayed:

Symptoms: None known

Hazards: Other dangerous properties can not be excluded.

Indication of any immediate medical attention and special treatment needed:

This substance does not have any noteworthy noxious potential. Damage to health is thus not expected.

Fire-fighting measures

Extinguishing media:

Suitable extinguishing media:       Water spray jet

             Foam

             Carbon dioxide (CO2)

             Dry powder

Unsuitable extinguishing media: Do not use a solid water stream as it may scatter and spread fire.

Special hazards arising from the substance or mixture:

May be released in case of fire:

Carbon monoxide

Carbon dioxide (CO2)

Nitrogen oxides (NOx)

organic products of decomposition

Advice for firefighters:

Fire residues should be disposed of in accordance with the regulations.

Keep out unprotected persons.

Contaminated extinguishing water must be treated at a suitable disposal plant in accordance with waste management laws.

In case of fire, remove the endangered containers and bring to a safe place, if this can be done safely.

In the event of fire, wear self-contained breathing apparatus.

Full protective suit

Accidental release measures

Personal precautions, protective equipment and emergency procedures:

Keep unauthorized persons away.

Avoid dust formation.

Environmental precautions:

Observe regulations on prevention of water pollution (check, dam up, cover up).

Do not allow entrance in sewage water, soil, stretches of water, drainage systems, surface water.

If the product contaminates rivers and lakes or drains inform respective authorities.

Methods and material for containment and cleaning up:

Pick up mechanically and collect in a suitable container. Avoid formation of dust.

Pack and label wastes like the pure substance. Do not detach label from the delivery containers prior to disposal.

Disposal according to local authority regulations.

To absorb spilled substance an approved industrial vacuum cleaner is recommended. If necessary, the spilled substance should be moistened.

Reference to other sections:

Wear personal protective equipment; see section Exposure controls/personal protection

Handling and storage

Precautions for safe handling:

Ensure good ventilation during processing.

Avoid dust formation.

Do not inhale dusts.

Avoid residues of the product on the containers.

Conditions for safe storage, including any incompatibilities:

Advice on protection against fire and explosion:

Normal measures for preventive fire protection.

Further information: VDI 2263 "Dust fires and dust explosions; dangers, evaluation, preventive measures."

Storage:

Store in the original receptacle, keeping this tightly sealed, under cool and dry conditions.

Further information

In order to ensure due transportation, make certain that stacks are of the correct height, containers are securely fastened so as

not to fall off, and labelled according to the regulations.

German storage class:

4.2 - Pyrophoric and self-heating hazardous materials

Transport information

Land transport (UN RTDG/ADR/RID)

UN number:

UN 3088

Shipping

Labels:

4.2

SpecialProvisions

Inland waterway transport (UN RTDG/ADN(R))

UN number:

UN 3088

Shipping

Labels:

4.2

Remarks

Marine transport (UN RTDG/IMDG)

UN number:

UN 3088

Shipping information

Proper shipping name and description:

SELF-HEATING SOLID, ORGANIC, N.O.S.

Chemical name:

N-[4-[[(2-amino-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutaminsäure

Labels:

4.2

Marine pollutant

Remarks

Air transport (UN RTDG/ICAO/IATA)

UN number:

UN 3088

Shipping information

Proper shipping name and description:

Self-heating solid, organic, n.o.s.

Chemical name:

N-[4-[[(2-amino-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutaminsäure

Labels:

4.2

Remarks

SpecialProvisions

Exposure controls / personal protection

Control parameters:

Other information:

Contains no substances with occupational exposure limit values.

DNEL/DMEL values:

Remarks: No substance-related safety assessment is necessary / has been conducted for this product.

PNEC values:

Remarks: No substance-related safety assessment is necessary / has been conducted for this product.

Exposure controls:

Engineering measures:

Ensure suitable suction/aeration at the work place and with operational machinery.

Provide for installation of emergency shower and eye bath.

Personal protective equipment:

Respiratory protection:

When handling for a short time:

If dust occurs: Dust mask with P1 particle filter (Germany)

In the event of prolonged exposure during handling:

In the case of respirable dust, use self-contained breathing apparatus.

Note time limit for wearing respiratory protective equipment.

Hand protection:

Applies to handling for brief periods or of small amounts

Glove material       Nitrile, for example, Dermatril 740, Kächele-Cama Latex GmbH (KCL), Germany

Material thickness: 0.11 mm

Method: DIN EN 374

Applies to handling for longer periods or of large amounts:

Glove material       Nitrile/Chloroprene, for example, Nitopren 717, Kächele-Cama Latex GmbH (KCL), Germany

Material thickness: 0.65 mm

Method: DIN EN 374

Selection of protective gloves to meet the requirements of specific workplaces.

Suitability for specific workplaces should be clarified with protective glove manufacturers.

The information is based on our own tests, references from the literature and information from glove manufacturers, or derived by analogy with similar materials.

Remember that the useful time per day of a chemical protection glove may be much shorter than the permeation time determined according to EN 374 due to the many different influential factors involved (e.g. temperature).

Eye protection:

Safety glasses with side-shields conforming to EN166

or

When handling larger quantities: basket-shaped glasses

Skin and body protection:

Select materials and equipment for physical protection depending on the concentration and volume of hazardous substances and the workplace involved.

Hygiene measures:

Remove and wash contaminated clothing before re-use.

No eating, drinking, smoking, or snuffing tobacco at work.

Wash face and/or hands before break and end of work.

Avoid contact with skin and eyes.

Cleanse and apply cream to skin after work.

If there is the possibility of skin/eye contact, the indicated hand/eye/body protection should be used.

Avoid contact with skin, eyes, and clothing.

Wash contact areas after handling.

Take off clothing and shoes contaminated with product. Clean before reuse.

Do not eat, drink or smoke while working. Wash hands, and/or face before breaks and when workday is finished.

Protective measures:

The personal protective equipment used must meet the requirements of directive 89/686/EEC and amendments (CE certification).

Handle in accordance with good industrial hygiene and safety practice.

Stability and reactivity

Reactivity:

No further information available

Chemical stability:

Stable under normal conditions.

Possibility of hazardous reactions:

No further information available

Conditions to avoid:

Sun rays, heat, heat effect

Prevent entrance of air/oxygen.

Incompatible materials:

Oxidizing agents, Reducing agents, Bases, Acids, heavy metal ions, atmospheric oxygen

Hazardous decomposition products:

No hazardous decomposition products known.

Stable at room temperature.

Disposal considerations

Waste treatment methods:

Product:

Disposal according to local authority regulations.

Pack and label wastes like the pure substance. Do not detach label from the delivery containers prior to disposal.

Uncleaned packaging:

Do not reuse empty containers and dispose of in accordance with the regulations issued by the appropriate local authorities.

Waste Key Number:

The waste key number must be determined as per the European Waste Types List (decision on EU Waste Types List 2000/532/EC) in cooperation with the disposal firm / producing firm / official authority.