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EC number: 948-406-5 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- November 2019
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 020
- Report date:
- 2020
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 420 (Acute Oral Toxicity - Fixed Dose Method)
- Version / remarks:
- version December 2001
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 bis (Acute Oral Toxicity - Fixed Dose Procedure)
- Version / remarks:
- version May 2008
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1100 (Acute Oral Toxicity)
- Version / remarks:
- Version December 2002
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- 3a,4,7,7a-tetrahydro-1H-indene
- EC Number:
- 221-260-3
- EC Name:
- 3a,4,7,7a-tetrahydro-1H-indene
- Cas Number:
- 3048-65-5
- Molecular formula:
- C9H12
- IUPAC Name:
- 3a,4,7,7a-tetrahydro-1H-indene
- Reference substance name:
- 4-vinylcyclohexene
- EC Number:
- 202-848-9
- EC Name:
- 4-vinylcyclohexene
- Cas Number:
- 100-40-3
- Molecular formula:
- C8H12
- IUPAC Name:
- 4-vinylcyclohexene
- Reference substance name:
- Cyclopentadiene
- EC Number:
- 208-835-4
- EC Name:
- Cyclopentadiene
- Cas Number:
- 542-92-7
- Molecular formula:
- C5H6
- IUPAC Name:
- cyclopenta-1,3-diene
- Reference substance name:
- cis-1,2-Divinylcyclobutane
- Cas Number:
- 2422-85-7
- Molecular formula:
- C8H12
- IUPAC Name:
- cis-1,2-Divinylcyclobutane
- Reference substance name:
- Ethylbenzene
- EC Number:
- 202-849-4
- EC Name:
- Ethylbenzene
- Cas Number:
- 100-41-4
- Molecular formula:
- C8H10
- IUPAC Name:
- ethylbenzene
- Reference substance name:
- 5-vinylnorborn-2-ene
- EC Number:
- 221-259-8
- EC Name:
- 5-vinylnorborn-2-ene
- Cas Number:
- 3048-64-4
- Molecular formula:
- C9H12
- IUPAC Name:
- 5-vinylbicyclo[2.2.1]hept-2-ene
- Reference substance name:
- Cycloocta-1,5-diene
- EC Number:
- 203-907-1
- EC Name:
- Cycloocta-1,5-diene
- Cas Number:
- 111-78-4
- Molecular formula:
- C8H12
- IUPAC Name:
- cycloocta-1,5-diene
- Reference substance name:
- 3a,4,7,7a-tetrahydro-4,7-methanoindene
- EC Number:
- 201-052-9
- EC Name:
- 3a,4,7,7a-tetrahydro-4,7-methanoindene
- Cas Number:
- 77-73-6
- Molecular formula:
- C10H12
- IUPAC Name:
- 3a,4,7,7a-tetrahydro-4,7-methanoindene,
- Reference substance name:
- 3a,4,7,7a-tetrahydro-4-methyl-1H-indene
- EC Number:
- 231-021-5
- EC Name:
- 3a,4,7,7a-tetrahydro-4-methyl-1H-indene
- Cas Number:
- 7413-02-7
- Molecular formula:
- C10H14
- IUPAC Name:
- 4-methyl-3a,4,7,7a-tetrahydro-1H-indene
- Reference substance name:
- Combination of: 6-(cyclohex-3-en-1-yl)bicyclo[2.2.1]hept-2-ene 2-vinyl-1,2,3,4,4a,5,8,8a-octahydro-1,4-methanonaphthalene 6-vinyl-1,4,4a,5,6,7,8,8a-octahydro-1,4-methanonaphthalene 2-vinyl-1,2,3,4,4a,5,8,8a-octahydro-1,4:5,8-dimethanonaphthalene 2,2'-bi(bicyclo[2.2.1]heptane-5,5'-diene) 3a,4,4a,5,8,8a,9,9a-octahydro-1H-5,8-methanocyclopenta[b]naphthalene 4,4a,4b,5,8,8a,9,9a-octahydro-1H-1,4-methanofluorene
- Molecular formula:
- C13H18 to C14H18
- IUPAC Name:
- Combination of: 6-(cyclohex-3-en-1-yl)bicyclo[2.2.1]hept-2-ene 2-vinyl-1,2,3,4,4a,5,8,8a-octahydro-1,4-methanonaphthalene 6-vinyl-1,4,4a,5,6,7,8,8a-octahydro-1,4-methanonaphthalene 2-vinyl-1,2,3,4,4a,5,8,8a-octahydro-1,4:5,8-dimethanonaphthalene 2,2'-bi(bicyclo[2.2.1]heptane-5,5'-diene) 3a,4,4a,5,8,8a,9,9a-octahydro-1H-5,8-methanocyclopenta[b]naphthalene 4,4a,4b,5,8,8a,9,9a-octahydro-1H-1,4-methanofluorene
- Reference substance name:
- 4,4a,4b,5,8,8a,9,9a-octahydro-1H-1,4-methanofluorene OR 4,4a,4b,5,8,8a,9,9a-octahydro-1H-1,4:5,8-dimethanofluorene
- Molecular formula:
- C14H18 to C15H18
- IUPAC Name:
- 4,4a,4b,5,8,8a,9,9a-octahydro-1H-1,4-methanofluorene OR 4,4a,4b,5,8,8a,9,9a-octahydro-1H-1,4:5,8-dimethanofluorene
- Reference substance name:
- 3a,4,4a,5,8,8a,9,9a-octahydro-4,9:5,8-dimethano-1H-benz[f]indene
- EC Number:
- 230-512-1
- EC Name:
- 3a,4,4a,5,8,8a,9,9a-octahydro-4,9:5,8-dimethano-1H-benz[f]indene
- Cas Number:
- 7158-25-0
- Molecular formula:
- C15H18
- IUPAC Name:
- 3a,4,4a,5,8,8a,9,9a-octahydro-1H-4,9:5,8-dimethanocyclopenta[b]naphthalene
- Reference substance name:
- Tetramers of cyclopentadiene and 1,3-butadiene
- Molecular formula:
- C16H24 to C20H24
- IUPAC Name:
- Tetramers of cyclopentadiene and 1,3-butadiene
- Test material form:
- liquid
- Details on test material:
- Light brown liquid.
Batch number 776809
Constituent 1
Constituent 2
Constituent 3
Constituent 4
Constituent 5
Constituent 6
Constituent 7
Constituent 8
Constituent 9
impurity 1
Constituent 10
Constituent 11
Constituent 12
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 30 and 200mg/mL for the sighting and main study
- Amount of vehicle (if gavage): 10mL/kg
- Justification for choice of vehicle: solubility considerations
- Lot/batch no. (if required):
MAXIMUM DOSE VOLUME APPLIED: 2000mg/kg
DOSAGE PREPARATION (if unusual):
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: sighitng study using one animals each at doses of 300 and 2000mg/kg. In the absence of mortality at 2000mg/kg a further four animals were dosed at this concentration. - Doses:
- 300mg/kg and 2000mg/kg for range finder. 2000mg/kg for main study.
- No. of animals per sex per dose:
- Range finder: 1
Main study total: 5 (female only) - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Twice daily observations, weighing days 1, 8 and 15. Additional observations if toxic signs observed
- Necropsy of survivors performed: yes/no
- Examinations performed: clinical signs, body weight, gross pathology (brain, cecum, duodenum, heart, kidneys, small and large intestine, liver, lungs, bronchi, spleen, stomach, subcutaneous tissue, urinary bladder). - Statistics:
- not applicable
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- not determinable due to absence of adverse toxic effects
- Mortality:
- None
- Clinical signs:
- other: At 2000mg/kg: piloerection and underactivity in 4/5 animals. Resolved within 5 hours but observed again on day 2 (underactivity 4/5 animals, piloerection 2/5 animals). Absent from day 3 onwards.
- Gross pathology:
- No abnormalities noted
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Not classified as harmful under EU implementation of GHS
- Executive summary:
In a guideline and GLP fixed dose procedure acute oral toxicity study in rats, no lethality was observed in the 5 females exposed to a single gavage dose of 2000mg/kg during the 14 day observation period. Piloerection and slight underactivity was noted in most animals in the first two days and low body weight gain in a single animal from day 8 onwards. According to this result, this substance THI-TM does not need to be classified for acute toxicity by the oral route.
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