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Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation: in vivo (non-LLNA)
Type of information:
experimental study
Adequacy of study:
key study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1988
Report date:
1988

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 406 (Skin Sensitisation)
Deviations:
yes

Test material

Constituent 1

In vivo test system

Test animals

Species:
guinea pig
Strain:
Pirbright-Hartley
Sex:
female

Study design: in vivo (non-LLNA)

Induction
Route:
intradermal and epicutaneous
Challenge
Route:
epicutaneous, occlusive

Results and discussion

In vivo (non-LLNA)

Resultsopen allclose all
Reading:
other:
Hours after challenge:
48
Group:
other:
No. with + reactions:
0
Total no. in group:
10
Remarks on result:
other:
Reading:
other:
Hours after challenge:
72
Group:
other:
No. with + reactions:
0
Total no. in group:
10
Remarks on result:
other:
Reading:
other:
Hours after challenge:
48
Group:
test chemical
No. with + reactions:
20
Total no. in group:
20
Remarks on result:
other:
Reading:
other:
Hours after challenge:
72
Group:
test chemical
No. with + reactions:
19
Total no. in group:
20
Remarks on result:
other:
Reading:
other:
Hours after challenge:
48
Group:
other:
No. with + reactions:
2
Total no. in group:
10
Remarks on result:
other:
Reading:
other:
Hours after challenge:
72
Group:
other:
No. with + reactions:
2
Total no. in group:
10
Remarks on result:
other:
Reading:
other:
Hours after challenge:
48
Group:
test chemical
No. with + reactions:
18
Total no. in group:
20
Remarks on result:
other:
Reading:
other:
Hours after challenge:
72
Group:
test chemical
No. with + reactions:
15
Total no. in group:
20
Remarks on result:
other:

Applicant's summary and conclusion