Registration Dossier

Administrative data

Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
14 February 2018 to 14 March 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2018
Report Date:
2018

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Version / remarks:
11 July 2006
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
effusion method: isothermal thermogravimetry

Test material

Reference
Name:
Unnamed
Test material form:
liquid
Details on test material:
Appearance: Straw to yellow syrup
Purity/Composition: Not indicated
Test item storage: At room temperature

Additional information
Test Facility test item number: 209099/A
Purity/Composition correction factor: No correction factor required
Test item handling: No specific handling conditions required
Specific details on test material used for the study:
Appearance: Straw to yellow syrup
Purity/Composition: Not indicated
Test item storage: At room temperature

Additional information
Test Facility test item number: 209099/A
Purity/Composition correction factor: No correction factor required
Test item handling: No specific handling conditions required

Results and discussion

Vapour pressureopen allclose all
Key result
Test no.:
#1
Temp.:
ca. 293 K
Vapour pressure:
ca. 0 Pa
Key result
Test no.:
#2
Temp.:
ca. 298 K
Vapour pressure:
ca. 0 Pa

Any other information on results incl. tables

Representative weight loss curves of the test item are shown in the attached figure 4.

The vapour pressure regression curve constructed using the data of Experiment 1 and Experiment 2 had a coefficient of correlation of <0.99.

Therefore, it was decided to perform a third experiment and to calculate the coefficient of correlation for the Experiment 1/Experiment 2/Experiment 3, Experiment 1/Experiment 2, Experiment 1/Experiment 3 and Experiment 2/Experiment 3. Coefficient of correlation was >0.99 for the Experiment 2/Experiment 3. Based on this, the results from Experiment 1 were excluded.

 

The results of the isothermal TGA analysis for the test item are given inTable 3.

The vapour pressure at 20°Cand 25°Ccalculated using the curve obtained with data of Experiment 2/Experiment 3 is given inTable 4.

The plot of the log PT of the test item as function of the reciprocal temperatures is shown inFigure 5 (attached). The equation of the curve was: log PT = -5505´1/T + 13.47 (r = 0.996, n = 8).

Results of the Vapour pressure Isothermal TGA Analysis

Experiment

Temperature
[°C]

Weight loss
[µg/min]

νT
[g/cm2/h]

logνT

logPT

PT
[Pa]

 

 

 

 

 

 

 

11

130

0.720525

8.60´10-5

-4.07

-0.07

0.86

 

140

1.46824

1.75´10-4

-3.76

-0.33

2.1

 

150

2.16385

2.58´10-4

-3.59

-0.54

3.5

 

160

3.91086

4.67´10-4

-3.33

-0.87

7.5

 

 

 

 

 

 

 

2

130

0.635023

7.58´10-5

-4.12

-0.14

0.73

 

140

0.941651

1.12´10-4

-3.95

0.08

1.2

 

150

1.79553

2.14´10-4

-3.67

0.44

2.8

 

160

3.26571

3.90´10-4

-3.41

0.77

5.9

 

 

 

 

 

 

 

3

130

0.588752

7.03´10-5

-4.15

-0.18

0.66

 

140

1.04732

1.25´10-4

-3.90

0.14

1.4

 

150

1.86634

2.23´10-4

-3.65

0.46

2.9

 

160

3.35298

4.00´10-4

-3.40

0.79

6.1

 

 

 

 

 

 

 

1Experiment 1 was not used in calculation.

Vapour Pressure of the Test Item

Temperature
[°C]

logPT

PT
[Pa]

PT
[mm Hg]

20

-5.31

4.9´10-6

3.7´10-8

25

-4.99

1.0´10-5

7.6´10-8

Applicant's summary and conclusion

Conclusions:
The vapour pressure of the test substance was determined to be 0.0000049 Pa at 293 K, under the conditions of the test.
The vapour pressure of the test substance was determined to be 0.00001 Pa at 298 K, under the conditions of the test.
Executive summary:

In this guideline (OECD 104) study, [conducted with GLP certification]:

The vapour pressure of the test substance was determined to be 0.0000049 Pa at 293 K, under the conditions of the test.

The vapour pressure of the test substance was determined to be 0.00001 Pa at 298 K, under the conditions of the test.