Registration Dossier
Registration Dossier
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EC number: 944-732-7 | CAS number: -
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 25 May 2018 to 13 August 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - HPLC Method)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Type:
- log Pow
- Partition coefficient:
- < 1
- Temp.:
- 20 °C
- pH:
- 7
- Details on results:
- Two chromatographs of the test item were produced; one with and one without the deadtime standard. Based on these chromatograms it was concluded that the soluble components of the test item co-eluted with formamide. It was therefore concluded that the partition coefficient of the test item was less than that of the shortest eluting standard assessed (acetanilide) with a log10Pow value less than 1.0.
- Conclusions:
- The Log Pow of the test item was determined to be <1.
- Executive summary:
The partition coefficient of the test item was determined in an OECD 117 and EC Method A.8 guideline study. The Log Pow of the test item was determined to be <1.
The study is a GLP compliant, guideline experimental study and is fully acceptable for assessment of this endpoint.
Reference
Description of key information
The Log Pow of the test item was determined to be <1.
Key value for chemical safety assessment
Additional information
The partition coefficient of the test item was determined in an OECD 117 and EC Method A.8 guideline study (Dunning 2018).
The study is a GLP-compliant, guideline experimental study and is fully acceptable for assessment of this endpoint.
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