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EC number: 825-609-6
CAS number: 98458-83-4
An acute inhalation toxicity was performed equivalent to OECD 403 with
1,3H6XDI. Five male and female rats were exposed to aerosols for 4 hours
(whole body exposure) and followed for 14 days. Mortality was 0,
2, 1, 0, 9 and 10 rats at 0, 72.7, 114.7, 147.1, 239.1 and 531.6 mg/m3.
The time of death correlated with exposure consentration. During
exposure, rats showed salivation, lacrimation, hunched or prone posture,
peripheral vasodilation and laboured breathing (gasping at two highest
doses). The rapidity of onset of these reactions was related to the
exposure level. During observation period, laboured breathing and rales
were observed in all exposed animals. Brown staining (or dark red
discharge) around snouts and peripheral vasodilation was observed in all
rats 3 days post exposure. Persistence of the observations was dependent
on exposure concentration. Dose-dependent decrease in body weight gain
was noted during first 3 to 5 days after exposure. Subsequent body
weight gain was comparable to that of the control rats for rats dosed at
72.7 and 114.7 mg/m3, but for rats dosed higher body weight gain
remained lower, or further decreased (at 239.1 mg/m3). Gross macroscopy
revealed substance related effects in the lungs (oedema
and hepatisation, dose-dependent severity).
As the LD50 of 1,3-H6XDI was found to be > 147.1 mg/m3 and < 239 mg/m3,
which correlates to > 0.147 mg/L and < 0.239 mg/L, 1,3H6XDI is
classified as category 2 for inhalation toxicity according to
Regulation EC 1272/2008.
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