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EC number: 221-244-6 | CAS number: 3040-44-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation / corrosion: corrosive (cat. 1B)
Eye irritation: irreversible damage (cat. 1)
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: well-documented, scientifically acceptable study report
- Principles of method if other than guideline:
- according to BASF-internal standard
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- - Source: Gaukler, 6050 Offenbach/Main, Germany
- Acclimatization period: about 8 days before study start (same housing conditions as during the study).
- Single housing in stainless steel cages (floor area: 40 x 51 cm).
- Animal identification: via ear tattoo (= animal number).
- Room temperature: 20 - 26°C
- Relative humidity: 50 - 80%
- Day/night rhythm: 12 h light and 12 h darkness
- The rabbits were offered a standardized animal laboratory diet (about 130 g/animal/day) as well as tap water (about 250 ml/animal/day). - Type of coverage:
- occlusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated skin of the same animal
- Amount / concentration applied:
- Test patches with ca. 0.5 ml of the undiluted test substance.
- Duration of treatment / exposure:
- 1 hour
- Observation period:
- 8 days
- Number of animals:
- 2
- Details on study design:
- - Clipping of the fur: at least 15 hours before application of the test substance
- Application area: 2.5 x 2.5 cm
- Application site: upper third of the back
- After an exposure time of 1 h the test substance was washed off with Lutrol and Lutrol/water (1:1).
- Readings: 15 - 30 minutes after removal of the test patches and 24, 48 h and 8 d after application.
- Scoring according to J.H. Draize, 1959
- In the case of clinical evidence to necroses, the skin was cutted to allow a detailled macroscopical examination. - Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48 h
- Score:
- 0.5
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- After 8 days, the animals showed parchment-like and leather-like necrosis which was confirmed macroscopically by a pathologist.
- Interpretation of results:
- Category 1 (corrosive) based on GHS criteria
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: well-documented, scientifically acceptable study report
- Principles of method if other than guideline:
- according to BASF-internal standard
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- - Source: Gaukler, 6050 Offenbach/Main, Germany
- Acclimatization period: about 8 days before study start (same housing conditions as during the study).
- Single housing in stainless steel cages (floor area: 40 x 51 cm).
- Animal identification: via ear tattoo (= animal number).
- Room temperature: 20 - 26°C
- Relative humidity: 50 - 80%
- Day/night rhythm: 12 h light and 12 h darkness
- The rabbits were offered a standardized animal laboratory diet (about 130 g/animal/day) as well as tap water (about 250 ml/animal/day). - Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated skin of the same animal
- Amount / concentration applied:
- Test patches with the 0.5 ml of the undiluted test substance.
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 8 days
- Number of animals:
- 2
- Details on study design:
- - Clipping of the fur: at least 15 hours before application of the test substance
- Application area: 2.5 x 2.5 cm
- Application site: upper third of the back
- After an exposure time of 4 h the test substance was washed off with Lutrol and Lutrol/water (1:1).
- Readings: 15 - 30 minutes after removal of the test patches and 24, 48 h and 8 d after application.
- Scoring according to J.H. Draize, 1959
- In the case of clinical evidence to necroses, the skin was cutted to allow a detailled macroscopical examination. - Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: corrosive
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: corrosive
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 d
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- positive indication of irritation
- Irritant / corrosive response data:
- After 48 hours, the animals showed parchment-like necrosis that developed into deep necrosis within 8 days.
- Interpretation of results:
- Category 1 (corrosive) based on GHS criteria
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: well-documented, scientifically acceptable study report
- Principles of method if other than guideline:
- according to BASF-internal standard
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- - Source: Gaukler, 6050 Offenbach/Main, Germany
- Acclimatization period: about 8 days before study start (same housing conditions as during the study).
- Single housing in stainless steel cages (floor area: 40 x 51 cm).
- Animal identification: via ear tattoo (= animal number).
- Room temperature: 20 - 26°C
- Relative humidity: 50 - 80%
- Day/night rhythm: 12 h light and 12 h darkness
- The rabbits were offered a standardized animal laboratory diet (about 130 g/animal/day) as well as tap water (about 250 ml/animal/day). - Type of coverage:
- occlusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated skin of the same animal
- Amount / concentration applied:
- Test patches with ca. 0.5 ml of the undiluted test substance.
- Duration of treatment / exposure:
- 3 minutes
- Observation period:
- 8 days
- Number of animals:
- 2
- Details on study design:
- - Clipping of the fur: at least 15 hours before application of the test substance
- Application area: 2.5 x 2.5 cm
- Application site: upper third of the back
- After an exposure time of 3 min the test substance was washed off with Lutrol and Lutrol/water (1:1).
- Readings: 15 - 30 minutes after removal of the test patches and 24, 48 h and 8 d after application.
- Scoring according to J.H. Draize, 1959
- In the case of clinical evidence to necroses, the skin was cutted to allow a detailled macroscopical examination. - Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48 h
- Score:
- 0.5
- Max. score:
- 4
- Reversibility:
- fully reversible within: 8 d
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48 h
- Score:
- 0.5
- Max. score:
- 4
- Reversibility:
- fully reversible within: 8 d
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- No indictation of irritating effects after an exposure period of 3 minutes.
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vitro / ex vivo
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study need not be conducted because the available information indicates that the criteria are met for classification as corrosive to the skin or irritating to eyes
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation / corrosion
In well-documented, scientifically acceptable studies (non-guideline, non-GLP) the undiluted test substance was applied to the intact clipped skin (back) of Vienna White rabbits (2 female animals in each case). After an exposure period of 3 minutes, 1 and 4 hours (occlusive coverage) the test substance was washed of and the degree of skin irritation/corrosion was evaluated according to Draize at different time points (15 - 30 minutes after removal of the test patches and 24, 48 h and 8 d after application).
24 hours after the application of the test substance (1 h exposure period) erythemas occurred developing into severe necroses within further 24 hours that were not reversible. Simultaneously only slight edemas were observed.
An exposure period of 4 hours caused parchment-like necrosis 48 hours after application of the test substance, that developed into deep necrosis within 8 days.
No indication of any irritating effects was observed after 3 min exposure to the test substance.
Taking together these 3 studies, it can be concluded that the test substance has to be classified as skin corrosive Cat. 1B.
Eye irritation
Due to the skin corrosivity of the test substance an eye irritation study has not to be conducted according to Regulation No. 1907/2006 and corrosivity to the eye is assumed as well.
Justification for classification or non-classification
The available experimental test data are reliable and suitable for classification purposes under Regulation 1272/2008. As a result the substance has to be classified for skin corrosivity Cat. 1B and eye damage Cat. 1 under Regulation (EC) No. 1272/2008, as amended for the 13th time in Regulation (EU) 2018/1480.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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