Registration Dossier
Registration Dossier
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EC number: 266-840-7 | CAS number: 67656-24-0
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Remarks:
- : QSAR profiling of acute oral toxicity
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Justification for type of information:
- 1. SOFTWARE
OECD QSAR Toolbox: a Quantitative Structure-Activity Relationship model that was developed by the Laboratory of Mathematical Chemistry, Burgas, Bulgaria (http://toolbox.oasis-lmc.org).
2. MODEL (incl. version number)
OECD QSAR Toolbox version 4.2
3. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL
See “Test material information”
4. SCIENTIFIC VALIDITY OF THE (Q)SAR MODEL
See description of profilers in the attached documents.
5. APPLICABILITY DOMAIN
Profilers with relevance for acute oral toxicity were selected.
6. ADEQUACY OF THE RESULT
The results may be used in a weight-of-evidence approach together with other information to reach a conclusion regarding the acute oral toxicity of the test substance.
Data source
Reference
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: REACH Guidance on QSARs
- Deviations:
- not applicable
- Principles of method if other than guideline:
- The OECD QSAR Toolbox v4.2 is a Quantitative Structure-Activity Relationship model that was developed by the Laboratory of Mathematical Chemistry, Burgas, Bulgaria (http://toolbox.oasis-lmc.org).
- GLP compliance:
- no
- Test type:
- other: QSAR profiling
Test material
- Reference substance name:
- Sodium 2-butoxyethyl sulphate
- EC Number:
- 266-840-7
- EC Name:
- Sodium 2-butoxyethyl sulphate
- Cas Number:
- 67656-24-0
- Molecular formula:
- C6H14O5S.Na
- IUPAC Name:
- sodium 2-butoxyethyl sulphate
Constituent 1
Results and discussion
Effect levels
- Key result
- Dose descriptor:
- other: Toxic hazard classification by Cramer
- Remarks on result:
- other: Low toxicity
- Remarks:
- Class I
Applicant's summary and conclusion
- Interpretation of results:
- other: low acute oral toxicity
- Conclusions:
- The acute oral toxicity potential of 2-butoxyethyl sulphate was evaluated using OECD QSAR Toolbox v4.2. Profilers on toxic hazard classification by Cramer indicated low acute toxicity (Class I). Based on the QSAR profiling no acute oral toxicity is expected for 2-butoxyethyl hydrogen sulphate.
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