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EC number: 232-796-2
CAS number: 9025-49-4
The acute oral toxicity of the test substance was studied in rats
after administration of a single oral dose followed by an observation
period of 14 days. A preliminary sighting study, using one female
animal, was included in order to estimate the dose effect for toxicity
and to provide information on dose selection for the main study. The
study was conducted in accordance with OECD Guideline 420. The study was
initiated with a sighting study in one female rat, in which 2000 mg
total protein/kg body weight was examined in order to provide
information on dose selection for the main study. On the basis of the
results of the sighting study, the main study was performed in 4
additional female rats given a dose of 2000 mg total protein/kg body
All animals survived the treatment. Slight signs of toxicity
(piloerection and less activity) were observed among the animals on the
day of treatment. However, no signs of toxicity were observed on any of
the following days. All four animals had a normal body weight gain from
treatment until termination of the study. The post-mortem inspection
revealed no abnormalities. Under the experimental conditions, it was
found that the minimal lethal dose of the test substance was above 2000
mg total protein/kg body weight.
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