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Link to relevant study record(s)

Description of key information

Key value for chemical safety assessment

Bioaccumulation potential:
low bioaccumulation potential

Additional information

No specific study was performed on the absorption, distribution, metabolism and/or excretion (ADME) of WS405966. Its systemic availability after topical or oral administration is expected to be limited, because of its relatively high molecular weight (approx. 600 Da), low water solubility (< 1 mg/l) and high lipohilicity (log Pow > 6). Availability of WS405966 under a vapour state is unlikely, because of its low vapour pressure (3 x 10-5 Pa).

Based on the available data the bioacumulation potential cannot be judged. However, based on the favourable testing results, i.e. absence of adverse effects in any of the studies performed according to the REACH Regulation annexes VII and VIII, on the one hand and on the very low dermal and inhalative bioavailability of the substance (due to its physical-chemical properties) on the other hand there is no need for further investigations of a bioaccumulation potential.