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Diss Factsheets
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EC number: 246-002-7 | CAS number: 24057-28-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
- Endpoint:
- basic toxicokinetics, other
- Remarks:
- evaluation of available information
- Type of information:
- other: expert report
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Well documented expert statement based on a series of physicochemical and toxicology studies with WS400304.
- Executive summary:
No specific study was performed on the absorption, distribution, metabolism, excretion (ADME) of this substance (WS400304), but data currently available on physical-chemical properties and from in vivo and in vitro toxicology studies were evaluated.
The substance, WS400304, is a salt of p-toluene sulfonic acid and pyridine with molecular weights of 172 and 79 Da, respectively. The substance is well water soluble (> 700 g/L) and accordingly has low lipophilicity (Log10Pow< 1).
After oral administration WS400304 is absorbed and systemically distributed as can be deduced from the adverse effects on livers of male and female rats observed in the sub-acute repeated oral dose toxicity study.
Systemic availability of WS400304 after dermal application is expected to be low based on its hydrophilicity. In the skin irritation test no effects on rabbit skin were observed.
Availability of WS400304 under a vapour state will be very limited, because of its low vapour pressure (40 Pa at 20°C) and because it is a solid hygroscopic substance limiting its availability as an inhalable aerosol.
There is no information on metabolism of WS400304.
Based on the increased kidney weights of male rats observed in the sub-acute repeated oral dose toxicity study renal excretion of WS400304 is rather likely.
Bioaccumulation of WS400304 is very unlikely based on the high hydrophilicity.
Reference
Description of key information
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 100
Additional information
No specific study was performed on the absorption, distribution, metabolism, excretion (ADME) of this substance (WS400304), but data currently available on physical-chemical properties and from in vivo and in vitro toxicology studies were evaluated.
The substance, WS400304, is a salt of p-toluene sulfonic acid and pyridine with molecular weights of 172 and 79 Da, respectively. The substance is well water soluble (> 700 g/L) and accordingly has low lipophilicity (Log10Pow< 1).
After oral administration WS400304 is absorbed and systemically distributed as can be deduced from the adverse effects on livers of male and female rats observed in the sub-acute repeated oral dose toxicity study.
Systemic availability of WS400304 after dermal application is expected to be low based on its hydrophilicity. In the skin irritation test no effects on rabbit skin were observed.
Availability of WS400304 under a vapour state will be very limited, because of its low vapour pressure (40 Pa at 20°C) and because it is a solid hygroscopic substance limiting its availability as an inhalable aerosol.
There is no information on metabolism of WS400304.
Based on the increased kidney weights of male rats observed in the sub-acute repeated oral dose toxicity study renal excretion of WS400304 is rather likely.
Bioaccumulation of WS400304 is very unlikely based on the high hydrophilicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.