Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 253-897-8 | CAS number: 38353-09-2
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- The determination was carried out using a flask method, designed to address the data endpoint of Method A.6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.
The test system consisted of purified water. - Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
Test material
- Reference substance name:
- Pyrimidine-2-ol hydrochloride
- EC Number:
- 253-897-8
- EC Name:
- Pyrimidine-2-ol hydrochloride
- Cas Number:
- 38353-09-2
- Molecular formula:
- C4H4N2O.ClH
- IUPAC Name:
- pyrimidin-2-ol hydrochloride
- Test material form:
- solid: particulate/powder
Constituent 1
Results and discussion
Water solubility
- Key result
- Water solubility:
- >= 65 - <= 67 vol%
- Conc. based on:
- test mat. (dissolved fraction)
- Temp.:
- 20 °C
- pH:
- >= 0.1 - <= 1.3
- Remarks on result:
- other: Due to the very high solubility of the test item in water, the standard regulatory method of preparing solutions at five times saturation concentration and analyzing the isolated solution for analysis was not considered relevant or feasible. The solubilit
Applicant's summary and conclusion
- Conclusions:
- Due to the very high solubility of the test item in water, the standard regulatory method of preparing solutions at five times saturation concentration and analyzing the isolated solution for analysis was not considered relevant or feasible. The solubility was therefore evaluated visually using a procedure based on the flask method specified in Method A.6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.
The water solubility of the test item has been determined to be in the range 65.0 to 67.3% w/w of solution at 20.0 ± 0.5 °C.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
