Registration Dossier
Registration Dossier
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EC number: 253-897-8 | CAS number: 38353-09-2
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Version / remarks:
- The determination was carried out using a shake-flask method, designed to be compatible with Method A.8 Partition Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 107 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.
The test system consisted of an aqueous and an n-octanol phase in the same vessel. A defined amount of test item was added (pre-dissolved in the appropriate phase) and partitioning of the test item between the two phases achieved by repeated inversion of the mixture. The test system temperature was in the range of 20 °C to 25 °C and kept constant (± 1 °C). - Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- Pyrimidine-2-ol hydrochloride
- EC Number:
- 253-897-8
- EC Name:
- Pyrimidine-2-ol hydrochloride
- Cas Number:
- 38353-09-2
- Molecular formula:
- C4H4N2O.ClH
- IUPAC Name:
- pyrimidin-2-ol hydrochloride
- Test material form:
- solid: particulate/powder
Constituent 1
Results and discussion
Partition coefficient
- Key result
- Type:
- log Pow
- Partition coefficient:
- ca. -1.61
- Temp.:
- 20.5 °C
- pH:
- >= 5.6 - <= 6.5
Applicant's summary and conclusion
- Conclusions:
- The partition coefficient of the test item has been determined to be 2.47 x 10-2 at 20.5 ± 0.5 °C, log10 Pow -1.61.
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