ucb 22060

Adsorption / desorption

Administrative data

Endpoint:

adsorption / desorption: screening

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2003-2004

Reliability:

1 (reliable without restriction)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2004

Report date:

2004

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))

Version / remarks:

Calculation using regression equations

GLP compliance:

yes

Media:

soil

Test material

Test material information

Constituent 1

Test material form:

solid: particulate/powder

Remarks:

migrated information: powder

Results and discussion

Adsorption coefficient

Type:

log Koc

Value:

-0.3

Results: HPLC method

Details on results (HPLC method):

The log of the adsorption coefficient (kc) of ucb 22060 was estimated to be
log KOC= -0.3 which is equal to a Koc value of 0.5
using the HPLC method. This value indicates that ucb 22060 will not be absorbed by organic
carbon in soil and that ucb 22060 is very high mobile.

Applicant's summary and conclusion

Conclusions:

The log of the adsorption coefficient (kc) of ucb 22060 was estimated to be
log KOC= -0.3 which is equal to a Koc value of 0.5
using the HPLC method. This value indicates that ucb 22060 will not be absorbed by organic
carbon in soil and that ucb 22060 is very high mobile.

Executive summary:

The determination of the adsorption coefficient (Koc) of ucb 22060 was pedormed according to the OECD Guideline for the Testing of Chemicals, No. 121, Estimation of the Adsorption Coefficient (Koc) on Soil and Sewage Sludge using High Performance Liquid Chromatography (HPLC), January, 2001 and the EC Directive 2001/59, C.19. The test item solution was injected three times and the combined reference solution was injected six times. The log Koc was calculated using a regression curve (log k’ vs. log Koc) and was found to be -0.3 which is equal to a Koc value of 0.5. In the present study the reference items covered the range of log Koc 1.25 to log Koc 5.63. An example of an HPLC chromatogram of the reference standard mixture is shown in Figure 1. An HPLC chromatogram of a test item solution is shown in Figure 2. A typical chromatogram of the determination of the dead-time is given in Figure 3. The chromatography of the test item resulted in one main peak with a well-defined and reproducible retention time. The HPLC method was therefore considered to be suitable for the purpose of the study. Based on the chromatographic data, ucb 22060 was considered to be stable during the test procedure. The retention times of the individual measurements of the reference items, test item and the dead time are given in Table 1. The capacity factor (k’) was calculated for each reference item using the retention times. Log &c was plotted versus log k for each component to obtain a regression curve (Table 2 and Figure 4). The retention time of ucb 22060 in the HPLC chromatogram is shorter than the retention time of the lowest reference item used. Therefore, the logarithm of the adsorption coefficient of ucb 22060 was extrapolated from the regression curve to be -0.3 (see Table 3). The Koc of ucb 22060 was calculated to be 0.5. The tabulated values represent rounded mean results, which were obtained by calculation using the exact raw data. In conclusion, the log of the adsorption coefficient (Koc) of ucb 22060 was estimated to be log KOC = -0.3 which is equal to a Kocvalue of 0.5 using the HPLC method. This value indicates that ucb 22060 will not be absorbed by organic carbon in soil and that ucb 22060 is very high mobile.