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EC number: 212-506-0 | CAS number: 822-89-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- April 6, 1994-May 4, 1994
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: US EPA FIFRA Pesticide Assessment Guidelines
- Version / remarks:
- 1984
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Hydroxyl-2-pyridone
- EC Number:
- 212-506-0
- EC Name:
- Hydroxyl-2-pyridone
- Cas Number:
- 822-89-9
- Molecular formula:
- C5H5NO2
- IUPAC Name:
- 1-hydroxy-1,2-dihydropyridin-2-one
- Test material form:
- solid: particulate/powder
- Details on test material:
- - Name of test material (as cited in study reports): Oxy PYRION
- Physical state: solid (powder)
- Appearance: white speckled gold powder
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: 93100020
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: Room temperature, glass jar
- Stability under test conditions: stable
Test animals
- Species:
- rat
- Strain:
- other: CD strain, remote Sprague-Dawley origin
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Limited, Margate, Kent, England
- Females (if applicable) nulliparous and non-pregnant: [yes/no] not specified
- Age at study initiation: young rats, approximately 5 weeks old.
- Weight at study initiation: Males-103-154 g; Females 104-132 g
- Fasting period before study: 24 h prior to dosing
- Housing:Stainles steel grid cages, 5 per cage, same sex
- Diet (e.g. ad libitum): Pelleted rodent diet, Special Diets Services Limited, Witham, Essex, England, ad libitum
- Water (e.g. ad libitum):ad libitum
- Acclimation period:5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19-25 degrees C
- Humidity (%): 40-70%
- Air changes (per hr): 10
- Photoperiod (hrs dark / hrs light): 12 dark/12 light
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- methylcellulose
- Details on oral exposure:
- VEHICLE
- Amount of vehicle (if gavage): 0.5% methylcellulose
MAXIMUM DOSE VOLUME APPLIED: 20 ml/kg
- Doses:
- 800, 1265, 2000, and 5000 mg.kg
- No. of animals per sex per dose:
- 5 males, 5 females, 800 mg/kg; 5 females, 1265 mg/kg; 5 males, 5 females, 2000 mg/kg; 5 males, 5000 mg/kg.
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Observations were made 3 times in the first hour, 2 more in day 1, and then 2 inspections and 1 recording daily thereafter. Weighed the day before dosing, and days 1, 8 and 15
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight - Statistics:
- LD50 calculations were conducted via Probit analysis.
Results and discussion
- Preliminary study:
- Yes. 1 male, 1 female each dose, at 400, 800, and 1000 mg/kg.
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 723 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 1 205 - <= 2 241
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 765 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 820 - <= 2 709
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 1 596 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 1 228 - <= 1 964
- Mortality:
- 1 female at 1265 mg/kg, 2 males, 4 females at 2000 mg/kg, 5 males at 5000 mg/kg:
mortality males and females: 0/1 at 400 mg/kg
mortality males 1/1 and females 0/1 at 800 mg/kg
mortality males 1/1 and females 1/1 at 2000 mg/kg - Clinical signs:
- Ante mortem signs comprised underactivity, prone position, pallor, clonic or tonic convulsions, muscle spasticity, muscle tremor, pigmented orbital secretion and salivation.
Signs of reaction to treatment in the surviving animals comprised underactivity, staggering gait, muscle tremor, muscle fasciculations, piloerection, hairloss and hunched posture. The majority of animals were overtly normal from day 2, although two male animals treated at 800 mg/kg showed hairloss throughout the second week of the observation period. - Body weight:
- Surviving animals achieved expected body weight gains over the course of the study.
- Gross pathology:
- Necropsy revealed no sinificant macroscopic lesions.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The test substance was found to have an LD50 of 1723 mg/kg in both sexes of rats, with a 95% confidence level of 1205-2241 mg/kg. Therefore, the substance is classified as Cat 4 under GHS.
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