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Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

Administrative data

Endpoint:
toxicity to aquatic algae and cyanobacteria
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Automatic calculation with MeCLas tool
Cross-referenceopen allclose all
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to other study

Data source

Reference
Reference Type:
other: software
Title:
RESHS MECLAS: Metals Classification Tool, version V5.0
Author:
ARCHE Consulting
Year:
2018
Bibliographic source:
MECLAS webpage: www.meclas.eu
Report date:
2018

Materials and methods

Principles of method if other than guideline:
Aquatic toxicity of the UVCB substance was determined by classifying based on Mixture rules from EU CLP (tier 1= summation of classified components or Tier 2 = additivity of soluble components to derive Hazard class) and back calculation to the corresponding L(E)C50 range

Test material

Constituent 1
Chemical structure
Reference substance name:
Germanium dioxide
EC Number:
215-180-8
EC Name:
Germanium dioxide
Cas Number:
1310-53-8
Molecular formula:
GeO2
IUPAC Name:
Germanium dioxide
Constituent 2
Chemical structure
Reference substance name:
Germanium
EC Number:
231-164-3
EC Name:
Germanium
Cas Number:
7440-56-4
Molecular formula:
Ge
IUPAC Name:
germanium (metallic form) equivalent
Constituent 3
Chemical structure
Reference substance name:
Silicon dioxide
EC Number:
231-545-4
EC Name:
Silicon dioxide
Cas Number:
7631-86-9
Molecular formula:
O2Si
IUPAC Name:
dioxosilane equivalent
Constituent 4
Chemical structure
Reference substance name:
Sodium chloride
EC Number:
231-598-3
EC Name:
Sodium chloride
Cas Number:
7647-14-5
Molecular formula:
ClNa
IUPAC Name:
sodium chloride
Constituent 5
Chemical structure
Reference substance name:
Aluminium oxide
EC Number:
215-691-6
EC Name:
Aluminium oxide
Cas Number:
1344-28-1
Molecular formula:
Al2O3
IUPAC Name:
Aluminium oxide equivalent
Constituent 6
Chemical structure
Reference substance name:
Calcium oxide
EC Number:
215-138-9
EC Name:
Calcium oxide
Cas Number:
1305-78-8
Molecular formula:
CaO
IUPAC Name:
Calcium oxide equivalent
Constituent 7
Chemical structure
Reference substance name:
Lead oxide
EC Number:
215-626-1
EC Name:
Lead oxide
Cas Number:
1335-25-7
Molecular formula:
PbO
IUPAC Name:
Lead oxide equivalent
Constituent 8
Chemical structure
Reference substance name:
Nickel monoxide
EC Number:
215-215-7
EC Name:
Nickel monoxide
Cas Number:
1313-99-1
Molecular formula:
NiO
IUPAC Name:
Nickel (II) oxide equivalent
Constituent 9
Chemical structure
Reference substance name:
Copper oxide
EC Number:
215-269-1
EC Name:
Copper oxide
Cas Number:
1317-38-0
Molecular formula:
CuO
IUPAC Name:
copper (II) oxide equivalent
Test material form:
solid

Results and discussion

Effect concentrations
Duration:
72 h
Dose descriptor:
EC50
Effect conc.:
<= 1 mg/L
Nominal / measured:
estimated
Conc. based on:
test mat.
Basis for effect:
other: most sensitive species

Any other information on results incl. tables

According to MeClas, the substance is classified as acute 1 to environment.

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
Good quality estimate of the L/EC50 of the UVCB substance.
The substance is classified as acute cat 1 to environment resulting in a L(E)C50 <= 1 mg/L.
Executive summary:

The study provided a conservative estimate of the effect concentration, derived on basis of the classification outcome (mixture toxicity rules) from a reasonable worst-case sample of the substance using mineralogical information from the representative sample. 

 

Validity of the model used:

1. Defined endpoint: the endpoint is a REACH compliant defined endpoint

2. Unambiguous algorithm: EU CLP guidance based summation formula to determine classification, followed by back-calculation to related hazard criteria

3. Applicability domain: applicable to classify complex metal containing materials. 

4. Mechanistic interpretation - metal species: the tool translates the elemental composition into a mineralogical composition relevant for classification.