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Diss Factsheets
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EC number: 905-570-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The effects of p-xylene to the early-life stage of fish (Danio rerio/ zebrafish) were determined according to OECD Guideline 210. An extended limit test was conducted under flow-through conditions with the nominal test item concentrations of 2.50 - 5.00 - 10.0 mg/L, corresponding to arithmetic mean measured test item concentrations of 0.714 – 1.29 – 2.79 mg/L. The NOEC and LOEC were determined to be 0.714 and 1.29 mg/L, respectively, based on post-hatch and overall survival.
The estimated NOELR values from TLM QSAR were 0.894 -1.134 mg/L.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 0.714 mg/L
Additional information
Noack (2017) measured the effects of p-xylene to the early-life stage of fish (Danio rerio/ zebrafish). The effects were determined according to OECD Guideline 210. An extended limit test was conducted under flow-through conditions with the nominal test item concentrations of 2.50 - 5.00 - 10.0 mg/L, corresponding to arithmetic mean measured test item concentration of 0.714 – 1.29 – 2.79 mg/L. The NOEC and LOEC were determined to be 0.714 and 1.29 mg/L respectively based on post-hatch and overall survival.
Walsh et al (1977) exposed adult fish to mixed xylenes for 56 days in a flow through system. Test concentrations were confirmed by analytical monitoring throughout the exposure period. Measured exposure concentrations were 0.36, 0.74 and 1.3 mg/L. No exposure linked mortality or changes in behaviour were observed at any of the test concentrations (NOEC >1.3mg/L). This study predates the implementation of GLP and study guidelines and deviates significantly from standard chronic fish toxicity tests. In particular, the use of adult fish in the chronic test and the choice of endpoints may result in a less sensitive result than if an embryo-larval or juvenile fish test had been conducted. However, it is well described and is acceptable for use bearing these restrictions in mind.
A TLM-EqP modeling framework was used to support values derived experimentally and are presented as supporting studies.
The estimated NOELR values from TLM QSAR were 0.894 - 1.134 mg/L.
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