Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2009
Report Date:
2009

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
GLP compliance:
yes
Type of method:
HPLC method
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Purity: 100%, as a reaction product

Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficient
Type:
Pow
Partition coefficient:
>= 3 - <= 7.2
Temp.:
25 °C
pH:
5

Any other information on results incl. tables

Partition Coefficient n-Octanol/water (25ºC)

Component

Rep. 1

Rep. 2

Average

DCDM-TAI

2.9

3

3

o-Cl-TAI

3.6

3.6

3.6

TCTM-HABI Isomer 1

5.1

5.1

5.1

TCTM-HABI Isomer 2

5.5

5.6

5.6

TCTM-HABI Isomer 3

5.8

5.8

5.8

TCDM-HABI Isomer 2

6.4

6.4

6.4

TCDM-HABI Isomer 1

6.7

6.7

6.7

o-Cl-HABI

7.2

7.2

7.2

Applicant's summary and conclusion

Conclusions:
Partition Coefficient n-Octanol/water (25ºC) was determined to be DCDM-TAI: 3, o-Cl-TAI: 3.6, TCTM-HABI Isomer 1: 5.1, TCTM-HABI Isomer 2: 5.6, TCTM-HABI Isomer 3: 5.8, TCDM-HABI Isomer 2: 6.4, TCDM-HABI Isomer 1: 6.7, o-Cl-HABI: 7.2.
Executive summary:

The test was run by the HPLC method (OECD 117). Six standard reference substances (methyl benzoate, ethyl benzoate, naphthalene, phenanthrene, dibenzyl and triphenylamine) were used. The test substance consists of eight separate components ranging in retention time from 6 to 70 min. The Partition Coefficient n-Octanol/water (25ºC) was determined to be DCDM-TAI: 3, o-Cl-TAI: 3.6, TCTM-HABI Isomer 1: 5.1, TCTM-HABI Isomer 2: 5.6, TCTM-HABI Isomer 3: 5.8, TCDM-HABI Isomer 2: 6.4, TCDM-HABI Isomer 1: 6.7, o-Cl-HABI: 7.2.