Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 942-252-2
CAS number: -
The single-dose oral toxicity study with Sopromine 1686 was performed
according to the acute toxic class method (OECD 423 and Commission
Regulation (EC) No 440/2008 of 30 May 2008, B.1.tris) in Crl:WI Wistar
female rats. Two groups of three female Crl:WI rats were treated by
gavage (single administration) with the test item at a dose level of
2000 mg active ingredient/kg body weight (bw) (Group 1 and Group 2).
Initially, three females (Group 1) were treated at a dose level of 2000
mg/kg bw. As no mortality was observed, a confirmatory group (Group 2)
was treated at the same dose level. No mortality was observed in the
confirmatory group; therefore, no further testing was required according
to OECD 423 and Commission Regulation (EC) No 440/2008 of 30 May 2008,
Clinical observations were performed at 30 minutes, 1, 2, 3, 4 and 6
hours after dosing and daily for 14 days thereafter. Body weight was
measured on Days -1, 0, 7 and before necropsy (Day 14). All animals were
subjected to a necropsy and a macroscopic examination.
Sopromine 1686 did not cause mortality at a dose level of 2000 mg/kg bw.
All animals were symptom-free during the observation period at a dose
level of 2000 mg/kg bw. There were no treatment related body weight
changes. Body weights were within the range commonly recorded for this
strain and age. There was no evidence of macroscopic changes at a dose
level of 2000 mg/kg bw.
Under the conditions of this study, the acute oral LD50 value of the
test item Sopromine 1686 was found to be above 2000 mg/kg bw in female
Crl:WI Wistar rats.
According the GHS criteria and considering the absence of mortality and
clinical signs at the dose of 2000 mg/kg bw, classification of Sopromine
1686 can be ranked as "Unclassified" for acute oral exposure.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again