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EC number: 942-252-2 | CAS number: -
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2017-10-03 / 2018-03-23
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Key result
- Water solubility:
- 0.257 g/L
- Conc. based on:
- test mat.
- Incubation duration:
- >= 288 - <= 336 h
- Temp.:
- 20 °C
- pH:
- >= 6.2 - <= 6.3
- Remarks on result:
- other: calculations were based on the quantitative analysis of the constituent Disodium C-(2-((1-oxooctadecyl)amino)ethyl) sulphonato-succinate (CAS RN 85081-55-6) (m/z 506.4)
- Conclusions:
- The water solubility of the test item at 20°C was 0.257 g/L.
- Executive summary:
The flask method was applied for the determination of the water solubility of the test item according to OECD Guideline 105 and EU Method A.6. The water solubility of the test item at 20°C was 0.257 g/L. The pH of the aqueous samples was 6.2 and 6.3.
Reference
Preliminary Test
The content of test item dissolved in the water sample was 0.115 g/L.
Main Study
The results for the samples taken at 288, 312 and 336 hours are given in the table below. The maximum difference of the concentrations determined in the 288, 312 and 336 hour test samples was ≤ 15%. Based on this, the water solubility of the test item is given as the mean value of the analyzed concentrations. A small response at the retention time of the test item was detected in the sample from the blank water mixture diluted in a 1:4 (v:v) ratio with tetrahydrofuran. This was probably caused by carry-over and as no impact on the outcome of the study. The concentration could not be calculated due to the cut off of the calibration curve.
Stirring time |
Analyzed concentration |
Mean |
Maximum difference |
pH |
|
|
|
|
|
288 |
0.259 |
0.257 |
5.7 |
6.3 |
|
|
|
|
|
312 |
0.248 |
|
|
6.3 |
|
|
|
|
|
336 |
0.263 |
|
|
6.2 |
Description of key information
The flask method was applied for the determination of the water solubility of the test item according to OECD Guideline 105 and EU Method A.6. The water solubility of the test item at 20°C was 0.257 g/L. The pH of the aqueous samples was 6.2 and 6.3.
Key value for chemical safety assessment
- Water solubility:
- 0.257 g/L
- at the temperature of:
- 20 °C
Additional information
One reliable experimental study is available and is selected as key study (Charles River, 2018). It was performed according to OECD Guideline 105 and EU Method A.6, and under GLP principles.
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