Registration Dossier

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
not specified
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature

Data source

Reference
Reference Type:
publication
Title:
Fragrance raw materials monographs - Methyl propionate
Author:
Opdyke, D.L.J & Letizia, C.
Year:
1982
Bibliographic source:
Food and Chemical Toxicology V20 1982 p765

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Publication data does not specify the method.

Reference to orignal publication: Moreno, O.M. (1977) Report to RIFM, 7 October
GLP compliance:
not specified
Test type:
other: Not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
not specified

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Conclusions:
According to information in secondary literature, the acute dermal LD50 of the substance to the rabbit is in excess of 5000 mg/kg.
Executive summary:

According to information in secondary literature, the acute dermal LD50 of the substance to the rabbit is in excess of 5000 mg/kg.