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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
not specified
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
Valid with restrictions. This is peer reviewed data where the test methodology and identity of the substance have been evaluated, and a reliable and representative value for the endpoint has been selected. No information on GLP status or test guideline followed is available.

Data source

Reference
Reference Type:
review article or handbook
Title:
Sax’s Dangerous Properties of Industrial Materials, 11th Edition, Volume 3
Author:
Lewis Sr., R.J.
Year:
2004
Bibliographic source:
Sax’s Dangerous Properties of Industrial Materials, 11th Edition, Volume 3

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Handbook data does not specify the method. Data from peer reviewed source.
GLP compliance:
not specified
Test type:
other: Handbook data does not specify the method. Data from peer reviewed source.

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid

Test animals

Species:
other: rat, mouse and rabbit
Strain:
not specified

Administration / exposure

Route of administration:
oral: unspecified

Results and discussion

Effect levelsopen allclose all
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
5 000 mg/kg bw
Based on:
not specified
Remarks on result:
other: rat
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
3 460 mg/kg bw
Based on:
not specified
Remarks on result:
other: mouse
Key result
Sex:
not specified
Dose descriptor:
LDLo
Effect level:
2 550 mg/kg bw
Based on:
not specified
Remarks on result:
other: rabbit

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Conclusions:
According to the handbook data the acute oral LD50 to rats is 5000 mg/kg, the acute oral LD50 to mice is 3460 mg/kg and the lethal dose low to the rabbit is 2550 mg/kg.
Executive summary:

According to the handbook data the acute oral LD50 to rats is 5000 mg/kg, the acute oral LD50 to mice is 3460 mg/kg and the lethal dose low to the rabbit is 2550 mg/kg.