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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
not specified
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
Valid with restrictions. This is peer reviewed data where the test methodology and identity of the substance have been evaluated, and a reliable and representative value for the endpoint has been selected. No information on GLP status or test guideline followed is available.

Data source

Reference
Reference Type:
review article or handbook
Title:
Sax’s Dangerous Properties of Industrial Materials, 11th Edition, Volume 3
Author:
Lewis Sr., R.J.
Year:
2004
Bibliographic source:
Sax’s Dangerous Properties of Industrial Materials, 11th Edition, Volume 3

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Handbook data does not specify the method. Data from peer reviewed source.
GLP compliance:
not specified
Test type:
other: Handbook data does not specify the method. Data from peer reviewed source.

Test material

Constituent 1
Chemical structure
Reference substance name:
Methyl propionate
EC Number:
209-060-4
EC Name:
Methyl propionate
Cas Number:
554-12-1
Molecular formula:
C4H8O2
IUPAC Name:
methyl propanoate
Test material form:
liquid

Test animals

Species:
other: rat, mouse and rabbit
Strain:
not specified

Administration / exposure

Route of administration:
oral: unspecified

Results and discussion

Effect levelsopen allclose all
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
5 000 mg/kg bw
Based on:
not specified
Remarks on result:
other: rat
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
3 460 mg/kg bw
Based on:
not specified
Remarks on result:
other: mouse
Key result
Sex:
not specified
Dose descriptor:
LDLo
Effect level:
2 550 mg/kg bw
Based on:
not specified
Remarks on result:
other: rabbit

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Conclusions:
According to the handbook data the acute oral LD50 to rats is 5000 mg/kg, the acute oral LD50 to mice is 3460 mg/kg and the lethal dose low to the rabbit is 2550 mg/kg.
Executive summary:

According to the handbook data the acute oral LD50 to rats is 5000 mg/kg, the acute oral LD50 to mice is 3460 mg/kg and the lethal dose low to the rabbit is 2550 mg/kg.