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Diss Factsheets

Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
13 Dec 2017 to 19 Feb 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Version / remarks:
27 July 1995
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Other quality assurance:
ISO/IEC 17025 (General requirements for the competence of testing and calibration laboratories)
Type of method:
other: Slow stiring flask method
Specific details on test material used for the study:
- Appearance: Viscous amber liquid (determined by Charles River Den Bosch)
- Purity/Composition: >85%
- Test item storage: At room temperature
- Additional information
- Test Facility test item number: 209080/A
- Purity/Composition correction factor: No correction factor required
- Test item handling: No specific handling conditions required
- Molecular structure: Not indicated
- Molecular formula: C63H116O12
- Molecular weight: 1065.6
Water solubility:
< 0.001 mg/L
Conc. based on:
test mat.
Incubation duration:
24 h
Temp.:
25 °C
pH:
6.3
Water solubility:
< 0.001 mg/L
Conc. based on:
test mat.
Incubation duration:
48 h
Temp.:
25 °C
pH:
6.2
Water solubility:
< 0.001 mg/L
Conc. based on:
test mat.
Incubation duration:
72 h
Temp.:
25 °C
pH:
6.2
Key result
Water solubility:
< 0.002 mg/L
Conc. based on:
test mat.
Incubation duration:
72 h
Temp.:
25 °C
pH:
6.2
Remarks on result:
other: Mean
Details on results:
Preliminary Test
The content of test item dissolved in the water sample was 0.00186 mg/L.

Main Study
The results for the samples taken at 24, 48 and 72 hours are given in Table 6. The maximum difference of the concentrations determined in the 24, 48 and 72 hour test samples was ≤ 15%. Since all values were calculated by extrapolation of the calibration curve water solubility is reported as lower than the lowest calibration point. A small response at the retention time of the test item was detected in the pretreated sample from the blank water mixture. It was considered to derive from carry-over since a similar response was found in the analytical blanks.

Table 6: Main study - wter solubility of the test item

Stirring time (hours) Analyzed concentration (mg/l)

Mean

(mg/l)

Maximum difference

(%)

 pH
24 0.0011* <0.0015** 4.8 6.3
48 0.0011*     6.2
72 0.0011*     6.2

* Estimated value, calculated by the extrapolation of the calibration curve.

** Based on the lowest concentration level of the calibration curve and taking a dilution factor of 5 into account.

Conclusions:
The water solubility of the test substance was found to be <0.0015 mg/l at 25 °C, under the conditions of the test.
Executive summary:

In this guideline (OECD 105) study, conducted with GLP certification, the water solubility of the test substance was found to be < 0.0015 mg/l at 25 °C.

Description of key information

Study conducted to recognised testing guidelines [with GLP certification].

Key value for chemical safety assessment

Additional information

In this guideline (OECD 105) study, conducted with GLP certification, the water solubility of the test substance was found to be < 0.0015 mg/l at 25 °C.