Registration Dossier
Registration Dossier
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EC number: 500-344-6 | CAS number: 157627-94-6 1 - 2.5 moles ethoxylated
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- Only limited information on the test material are available.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- 68891-38-3 (purity 70%)
- IUPAC Name:
- 68891-38-3 (purity 70%)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- According to Guideline.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 2000, 3200, 4000, 5000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 4 100 mg/kg bw
- Based on:
- test mat.
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2 870 mg/kg bw
- Based on:
- act. ingr.
- Mortality:
- There were deaths among animals dosed at 4000 and 5000 mg/kg bw.
- Clinical signs:
- other: Signs of reaction to treatment observed in all rats that survived for more than one hour after dosing were piloerection, hunched posture, abnormal gait (waddling), lethargy and diarrhoea. These were accompanied by: - decreased respiratory rate and pallor
- Gross pathology:
- No effects.
Applicant's summary and conclusion
- Interpretation of results:
- other: CLP/EU GHS criteria not met, no classification required according to Regulation (EC) No 1272/2008.
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