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Description of key information

Short description of key information on bioaccumulation potential result: 
From the study it is clear that DADPM/DEG-PO does undergo biotransformation in incubations with human liver microsomes indicating metabolism and no possible bioaccumolation potential.

Key value for chemical safety assessment

Bioaccumulation potential:
no bioaccumulation potential

Additional information

The metabolism of DADPM/DEG-PO was investigated using human liver microsomes. DADPM/DEG-PO (50 and 200 mg/L) was incubated with pooled human liver microsomes (0.5 and 2.0 mg/mL), pre-treated with alamethicin and in the presence of NADPH and UDPGA, for up to 120 minutes. The LC-MS analysis of the human liver microsome incubation samples was carried out. From the result shows that the test compound mixture (DADPM/DEG-PO) undergoes biotransformation in incubations with human liver microsomes pre-treated with alamethicin to enable access of substrates to the UGT active site and in the presence of the enzyme cofactors NADPH (for oxidative metabolism) and UDPGA (for glucuronic acid conjugation), as far as the aromatic components in the mixture are concerned. The data derived from the 2 hour incubations at both microsomal protein concentrations show the presence of glucuronide conjugates of the main aromatic components of the test compound mixture.

Based on information from the read-across, a similar pathway of metabolism is described (Paul Illing Consultancy Services Ltd. and Marlin Consultancy, 2007).

There are no toxicokinetic data for propoxylated diaminotoluene. The propoxylated diaminotoluene is made from o-diaminotoluene. Commercialo-toluenediamine is a mixture of 40% toluene-2,3-diamine and 60% 4-methyl-o-phenylenediamine. The toxicokinetics of propoxylated diaminotoluene is inferred from the read across from toluene-2,4-diamine and toluene-2,6-diamine to the toluene-2,3-diamine and 4-methyl-o-phenylene diamine and from propane-1,2-diol, oxydipropanol and [(methylethylene)bis(oxy)]-dipropanol. Diaminotoluene has two free amino groups, thus no longer polymer oligomers are likely to consist predominantly of chains of between one and two monomers.