Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
08/07/2015-06/18/2015
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2015
Report Date:
2015

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient - Shake Flask Method)
GLP compliance:
yes (incl. certificate)
Type of method:
flask method
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent
Specific details on test material used for the study:
100 mL sample received on 08/07/2015.
Presented as a colourless translucent liquid.
Batch number : 100026324
Substance certified 97.5% for isomer 1 of Maderal.
Stored at room temperature protected from direct sunlight

Study design

Analytical method:
other: GC-FID

Results and discussion

Partition coefficientopen allclose all
Key result
Type:
log Pow
Partition coefficient:
>= 4.32 - <= 4.4
Temp.:
20 °C
pH:
ca. 7.2
Key result
Type:
log Pow
Partition coefficient:
>= 4.38 - <= 4.49
Temp.:
20 °C
pH:
ca. 7.2

Applicant's summary and conclusion

Executive summary:

The partition coefficient was performed according to the EU Method A.8 (Partition Coefficient - Shake Flask Method).

The test substance has the following log P: 4.405 at 20°C, pH 7.2.