Registration Dossier
Registration Dossier
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EC number: 225-713-6 | CAS number: 5025-82-1
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2017
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 437 (Bovine Corneal Opacity and Permeability Test Method for Identifying Ocular Corrosives and Severe Irritants)
- Qualifier:
- according to guideline
- Guideline:
- EU method B.47 (Bovine corneal opacity and permeability test method for identifying ocular corrosives and severe irritants)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 3-acetylthiazolidine-4-carboxylic acid
- EC Number:
- 225-713-6
- EC Name:
- 3-acetylthiazolidine-4-carboxylic acid
- Cas Number:
- 5025-82-1
- Molecular formula:
- C6H9NO3S
- IUPAC Name:
- 3-acetylthiazolidine-4-carboxylic acid
Constituent 1
Test animals / tissue source
- Species:
- other: Bos primigenius Taurus (fresh bovine corneas)
Test system
- Vehicle:
- not specified
- Controls:
- yes, concurrent positive control
- yes, concurrent negative control
- Duration of treatment / exposure:
- duration less than four weeks
Results and discussion
In vitro
Results
- Irritation parameter:
- in vitro irritation score
- Value:
- ca. 66.44
- Negative controls validity:
- valid
- Positive controls validity:
- valid
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Conclusions:
- The test item 3-acetylthiazolidine-4-carboxylic acid induced serious eye damage on the cornea of the bovine eye.
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