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EC number: 701-249-4 | CAS number: -
NOAEL = 300 mg/kg b.wt./day for males and females
LOAEL = 1000 mg/kg b.wt./day for males and females based on increased adrenal weights and increased food consumption without commensurate body weight gain
This screening study, conducted in line with OECD Guideline 407 was designed to determine the potential subchronic toxicity, including neurotoxicity, of the test material administered to rats orally via gastric intubation once daily for at least four weeks (subchronic and neurotoxicity phases) and to evaluate the potential of the test material to adversely affect male and female reproductive performance (animals treated for four weeks prior to mating with treatment continuing throughout the ensuing mating and gestation period through to lactation Day 4). Dose levels for the subchronic toxicity and reproduction phases were 0 (vehicle [corn-oil] control), 50, 300 and 1000 mg/kg/day; group sizes in the subchronic toxicity study were 6 animals/sex/group and in the reproduction study 12 animals/sex/group.
In this screening study the no-observed effect level (NOEL) for subchronic toxicity was 300 mg/kg/day and for reproductive toxicity and neurotoxicity was 1000 mg/kg/day.
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