Registration Dossier
Registration Dossier
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EC number: 304-059-6 | CAS number: 94233-27-9
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- 2-ethylhexanol and pentane-2,4-dione are two main hydrolysis prodcuts of the target substance. Properties of the the two substance are used for read-across.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Acute toxicity of a homologous series of branched-chain primary alcohols
- Author:
- Scala, R.A.; Burtis, E.G.
- Year:
- 1 973
- Bibliographic source:
- American Industrial Hygiene Association Journal, 34, 1973, 493-499
- Reference Type:
- publication
- Title:
- 2-Ethylhexanol
- Author:
- BG-Chemie
- Year:
- 1 995
- Bibliographic source:
- Toxikologische Bewertungen, Programm zur Verhütung von Gesundheitsschädigungen durch Arbeitsstoffe
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- 2-ethylhexan-1-ol
- EC Number:
- 203-234-3
- EC Name:
- 2-ethylhexan-1-ol
- Cas Number:
- 104-76-7
- Molecular formula:
- C8H18O
- IUPAC Name:
- 2-ethylhexan-1-ol
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 2 600 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- LD50 value tested on rabbit was > 2600 mg/kg bw. 2 -ethylhexanol was therefore classified as Catagory 5 according to GHS.
- Executive summary:
As the target substance hydrolyses rapidly (half-life < 30 minutes) the intrinsic properties are related to hydrolysis products of the target substance. This information is used as a supporting evidence on the toxicity of the target substance in CSA.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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