Bis(2-ethylhexan-1-olato)bis(pentane-2,4-dionato-O,O')titanium

Short-term toxicity to fish

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

short-term toxicity to fish

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study

Justification for type of information:

2-ethylhexanol and pentane-2,4-dione are two main hydrolysis prodcuts of the target substance. Properties of the the two substance are used for read-across.

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 203 (Fish, Acute Toxicity Test)

GLP compliance:

not specified

Test organisms (species):

Pimephales promelas

Test type:

flow-through

Water media type:

freshwater

Total exposure duration:

96 h

Key result

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

ca. 28.2 mg/L

Nominal / measured:

meas. (arithm. mean)

Basis for effect:

mortality (fish)

Validity criteria fulfilled:

yes

Conclusions:

The 96h LC50, flow through method, tested on Pimephales promelas (Fathead minnow) was 28.2 mg/l.

Reference 2

Endpoint:

short-term toxicity to fish

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study

Justification for type of information:

2-ethylhexanol and pentane-2,4-dione are two main hydrolysis prodcuts of the target substance. Properties of the the two substance are used for read-across.

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 203 (Fish, Acute Toxicity Test)

GLP compliance:

no

Test organisms (species):

Pimephales promelas

Test type:

flow-through

Water media type:

freshwater

Total exposure duration:

96 h

Key result

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

ca. 104 mg/L

Nominal / measured:

meas. (arithm. mean)

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Validity criteria fulfilled:

yes

Conclusions:

The 96h LC50, flow though method, tesed on Pimephales promelas was 104 mg/l for pentane-2,4-dione.

Reference 3

Endpoint:

short-term toxicity to fish

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study

Justification for type of information:

2-ethylhexanol and pentane-2,4-dione are two main hydrolysis prodcuts of the target substance. Properties of the the two substance are used for read-across.

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 203 (Fish, Acute Toxicity Test)

GLP compliance:

not specified

Test organisms (species):

Lepomis macrochirus

Test type:

flow-through

Water media type:

freshwater

Total exposure duration:

96 h

Key result

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

ca. 60.1 mg/L

Basis for effect:

mortality (fish)

Details on results:

Confidence interval: 50.3 - 71.8 mg/l

Validity criteria fulfilled:

yes

Conclusions:

The 96h LC50, flow though type stuyd, tested on bluegill fish was 60.1 mg/l

Description of key information

Flow through method in fresh water. Test method equivalent or similar to guideline 302.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish

Effect concentration:

28.2 mg/L

Additional information

No studies were conducted on the target substance, Reaction product of Titanium tetrakis(2-ethylhexan-1-olato) and pentane-2,4-dione. As the target substance hydrolyses rapidly (half-life < 30 minutes) the intrinsic properties are related to hydrolysis products of the target substance.

On the basis that if entering the environmental, this substance will quickly dissociate to form the inorganic (poorly soluble) titanium dioxide and two well-evaluated organic substances – 2-ethylhexanol and pentane-2,4-dione. .

The titanium dioxide is not considered further in this report as aquatic toxicity assessments do not apply.

Short-term acute toxicity on fish studies are available on 2-ethylhexnaol and pentane-2,4-dione.

LC50 (96h) values tested either on Pimephales promelas or Lepomis macrochirus were 28.2 mg/l for 2-ethylhexanol (Geiger, D.L. et al., 1985),and 60.1 to 104 mg/l for pentane-2,4-dione (Thurston et al. 1985, Geiger, D.L. et al. 1984).

The lowest value of 28.2 mg/l for 2-ethylhexanol was chosen for CSA.