Registration Dossier

Administrative data

First-aid measures

SWALLOWED
· IF SWALLOWED, REFER FOR MEDICAL ATTENTION, WHERE POSSIBLE, WITHOUT DELAY. · Where Medical attention is not
immediately available or where the patient is more than 15 minutes from a hospital or unless instructed otherwise:
EYE
! If this product comes in contact with the eyes: · Immediately hold eyelids apart and flush the eye continuously with running water. · Ensure
complete irrigation of the eye by keeping eyelids apart and away from eye and moving the eyelids by occasionally lifting the upper and lower
lids.
SKIN
! If skin or hair contact occurs: · Quickly but gently, wipe material off skin with a dry, clean cloth. · Immediately remove all contaminated
clothing, including footwear.
INHALED
· If fumes or combustion products are inhaled remove from contaminated area. · Lay patient down. Keep warm and rested
NOTES TO PHYSICIAN
! For sub-chronic and chronic exposures to isocyanates:
· This material may be a potent pulmonary sensitizer which causes bronchospasm even in patients without prior airway hyperreactivity.
· Clinical symptoms of exposure involve mucosal irritation of respiratory and gastrointestinal tracts.

Fire-fighting measures

Vapour Pressure (mmHG): Not available
Upper Explosive Limit (%): Not available
Specific Gravity (water=1): Not available
Lower Explosive Limit (%): Not available
EXTINGUISHING MEDIA
· Small quantities of water in contact with hot liquid may react violently with generation of a large volume of rapidly expanding hot sticky
semi-solid foam.
· Presents additional hazard when fire fighting in a confined space.
· Cooling with flooding quantities of water reduces this risk.
· Water spray or fog may cause frothing and should be used in large quantities.
· Foam.
· Dry chemical powder.
FIRE FIGHTING
· Alert Emergency Responders and tell them location and nature of hazard.
· Wear full body protective clothing with breathing apparatus.
When any large container (including road and rail tankers) is involved in a fire,
consider evacuation by 800 metres in all directions.
GENERAL FIRE HAZARDS/HAZARDOUS COMBUSTIBLE PRODUCTS
· Combustible.
· Moderate fire hazard when exposed to heat or flame.
Combustion products include: carbon monoxide (CO), carbon dioxide (CO2), isocyanates, and minor amounts of, hydrogen cyanide,
hydrogen chloride, phosgene, nitrogen oxides (NOx), other pyrolysis products typical of burning organic material.
FIRE INCOMPATIBILITY
! Avoid contamination with oxidizing agents i.e. nitrates, oxidizing acids,chlorine bleaches, pool chlorine etc. as ignition may result.
PERSONAL PROTECTION
Glasses:
Chemical goggles.
Gloves:
Respirator:
Particulate

Accidental release measures

ACCIDENTAL RELEASE MEASURES
MINOR SPILLS
· Clean up waste regularly and abnormal spills immediately.
· Avoid breathing dust and contact with skin and eyes.
· Wear protective clothing, gloves, safety glasses and dust respirator.
· Use dry clean up procedures and avoid generating dust.
· Vacuum up or sweep up. NOTE: Vacuum cleaner must be fitted with an exhaust micro filter (HEPA type) (consider explosion-proof
machines designed to be grounded during storage and use).
· Dampen with water to prevent dusting before sweeping.
· Place in suitable containers for disposal.
MAJOR SPILLS
· Treat isocyanate spills with sufficient amounts of isocyanate decontaminant preparation.
· Typically, such a preparation may consist of: sawdust: 20 parts by weight Kieselguhr 40 parts by weight plus a mixture of {ammonia (s.g.
0.880) 8% v/v non-ionic surfactant 2% v/v water 90% v/v}.
· Let stand for 24 hours.
· Avoid contamination with water, alkalies and detergent solutions.
· Material reacts with water and generates gas, pressurises containers with even drum rupture resulting.
· DO NOT reseal container if contamination is suspected.
· Open all containers with care.
· Clear area of personnel and move upwind.
· Alert Emergency Responders and tell them location and nature of hazard.

Handling and storage

PROCEDURE FOR HANDLING
· Avoid all personal contact, including inhalation.
· Wear protective clothing when risk of exposure occurs.
Empty containers may contain residual dust which has the potential to accumulate following settling. Such dusts may explode in the
presence of an appropriate ignition source.
· Do NOT cut, drill, grind or weld such containers.
· In addition ensure such activity is not performed near full, partially empty or empty containers without appropriate workplace safety
authorisation or permit.
RECOMMENDED STORAGE METHODS
! Glass container.
· Lined metal can, Lined metal pail/drum
· Plastic pail.
For low viscosity materials
· Drums and jerricans must be of the non-removable head type.
· Where a can is to be used as an inner package, the can must have a screwed enclosure.
All inner and sole packagings for substances that have been assigned to Packaging Groups I or II on the basis of inhalation toxicity criteria,
must be hermetically sealed.
STORAGE REQUIREMENTS
· Store in original containers.
· Keep containers securely sealed.

Transport information

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Marine transport (IMDG)

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Exposure controls / personal protection

EXPOSURE CONTROLS
The following materials had no OELs on our records
• 3,4-dichlorophenyl isocyanate: CAS:102-36-3 CAS:25550-53-2
PERSONAL PROTECTION
RESPIRATOR
particulate.
EYE
· Safety glasses with side shields.
· Chemical goggles.
HANDS/FEET
! NOTE: The material may produce skin sensitization in predisposed individuals. Care must be taken, when removing gloves and other
protective equipment, to avoid all possible skin contact.
Suitability and durability of glove type is dependent on usage. Important factors in the selection of gloves include: such as:
· frequency and duration of contact,
· chemical resistance of glove material,
· glove thickness and
· dexterity
Select gloves tested to a relevant standard (e.g. Europe EN 374, US F739).
· When prolonged or frequently repeated contact may occur, a glove with a protection class of 5 or higher (breakthrough time greater than
240 minutes according to EN 374) is recommended.
· When only brief contact is expected, a glove with a protection class of 3 or higher (breakthrough time greater than 60 minutes according to
EN 374) is recommended.
· Contaminated gloves should be replaced.
Gloves must only be worn on clean hands. After using gloves, hands should be washed and dried thoroughly. Application of a non-perfumed
moisturiser is recommended.
· Isocyanate resistant materials include Teflon, Viton, nitrile rubber and some PVA gloves.
· Protective gloves and overalls should be worn as specified in the appropriate national standard.
· Contaminated garments should be removed promptly and should not be re-used until they have been decontaminated.
· NOTE: Natural rubber, neoprene, PVC can be affected by isocyanates.
OTHER
· Overalls.
· Eyewash unit.
ENGINEERING CONTROLS
· Local exhaust ventilation is required where solids are handled as powders or crystals; even when particulates are relatively large, a certain
proportion will be powdered by mutual friction.
· Exhaust ventilation should be designed to prevent accumulation and recirculation of particulates in the workplace.

Stability and reactivity

CONDITIONS CONTRIBUTING TO INSTABILITY
· Presence of incompatible materials.
· Product is considered stable.
STORAGE INCOMPATIBILITY
· Avoid reaction with water, alcohols and detergent solutions.
· Isocyanates and thioisocyanates are incompatible with many classes of compounds, reacting exothermically to release toxic gases.
Reactions with amines, strong bases, aldehydes, alcohols, alkali metals, ketones, mercaptans, strong oxidisers, hydrides, phenols, and
peroxides can cause vigorous releases of heat. Acids and bases initiate polymerisation reactions in these materials.
· Isocyanates easily form adducts with carbodiimides, isothiocyanates, ketenes, or with substrates containing activated CC or CN bonds.
· Some isocyanates react with water to form amines and liberate carbon dioxide. This reaction may also generate large volumes of foam and
heat. Foaming in confined spaces may produce pressure in confined spaces or containers. Gas generation may pressurise drums to the
point of rupture.
· Do NOT reseal container if contamination is expected
· Open all containers with care
· Base-catalysed reactions of isocyanates with alcohols should be carried out in inert solvents. Such reactions in the absence of solvents
often occur with explosive violence,
· Isocyanates will attack and embrittle some plastics and rubbers.
· A range of exothermic decomposition energies for isocyanates is given as 20-30 kJ/mol.
· The relationship between energy of decomposition and processing hazards has been the subject of discussion; it is suggested that values
of energy released per unit of mass, rather than on a molar basis (J/g) be used in the assessment.
· For example, in "open vessel processes" (with man-hole size openings, in an industrial setting), substances with exothermic decomposition
energies below 500 J/g are unlikely to present a danger, whilst those in "closed vessel processes" (opening is a safety valve or bursting
disk) present some danger where the decomposition energy exceeds 150 J/g.
BRETHERICK: Handbook of Reactive Chemical Hazards, 4th Edition.

Disposal considerations

Disposal Instructions
All waste must be handled in accordance with local, state and federal regulations.
" Puncture containers to prevent re-use and bury at an authorized landfill.
Legislation addressing waste disposal requirements may differ by country, state and/ or territory. Each user must refer to laws operating in
their area. In some areas, certain wastes must be tracked.
A Hierarchy of Controls seems to be common - the user should investigate:
· Reduction
· Reuse
· Recycling
· Disposal (if all else fails)
This material may be recycled if unused, or if it has not been contaminated so as to make it unsuitable for its intended use. Shelf life
considerations should also be applied in making decisions of this type. Note that properties of a material may change in use, and recycling
or reuse may not always be appropriate.
DO NOT allow wash water from cleaning equipment to enter drains. Collect all wash water for treatment before disposal.
· Recycle wherever possible.
· Consult manufacturer for recycling options or consult Waste Management Authority for disposal if no suitable treatment or disposal facility
can be identified.