Registration Dossier

Administrative data

Key value for chemical safety assessment

Genetic toxicity in vitro

Description of key information

- Genetic toxicity in vitro: Bacterial Reverse Mutation Assays equivalent to OECD Guideline 471 and 472 with the tester strains S. typhimurium TA 98, TA 100, TA 1535, TA 1537, TA 1538 and E. coli WP2 uvrA did not cause gene mutations by base pair changes or frameshifts in the genome with and without metabolic activation.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (negative)

Additional information

Justification for classification or non-classification

- Genetic toxicity in vitro:

Bacterial Reverse Mutation Assays equivalent to OECD Guideline 471 and 472 with the tester strains S. typhimurium TA 98, TA 100, TA 1535, TA 1537, TA 1538 and E. coli WP2 uvrA did not cause gene mutations by base pair changes or frameshifts in the genome with and without metabolic activation.

Therefore, the test item is considered to be non-mutagenic in these bacterial reverse mutation assays, no classification is warranted.