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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: scientifically acceptable

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1975
Report Date:
1975

Materials and methods

Principles of method if other than guideline:
3,4-dichlorophenyl isocyanate was diluted with Lutrol and administered, by intubation, to rats. The animals were given a volume equivalent to 0.5% of their body weight. Four groups of 5 males were given dose levels of 201, 342, 582 and 990 mg/kg and four groups of 5 females were given 41, 70, 118 and 201 mg/kg
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
no data

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
polyethylene glycol
Doses:
male: 201, 342, 582 and 990 mg/kg bw
female: 41, 79, 118 and 201 mg/kg bw
No. of animals per sex per dose:
5
Control animals:
not specified

Results and discussion

Effect levelsopen allclose all
Key result
Sex:
female
Dose descriptor:
LD50
Effect level:
91 mg/kg bw
Sex:
male
Dose descriptor:
LD50
Effect level:
402 mg/kg bw
Mortality:
male:
201 mg/kg: 0/5/5 (deaths/symptoms/no. exposed)
342 mg/kg: 2/5/5
582 mg/kg: 4/5/5
990 mg/kg: 5/5/5

female:
41 mg/kg: 1/5/5 (deaths/symptoms/no. exposed)
70 mg/kg: 0/5/5
118 mg/kg: 5/5/5
201 mg/kg: 4/5/5
Clinical signs:
lethargy, pilo erection, convulsions at high dose levels - all death occured within 24 hours post-treatment
Body weight:
no data
Gross pathology:
gastrointestinal inflammation

Any other information on results incl. tables

no further data

Applicant's summary and conclusion

Interpretation of results:
Category 3 based on GHS criteria
Conclusions:
LD50(male) = 402 mg/kg bw; LD50(female) = 91 mg/kg bw
Executive summary:

Method

3,4 -Dichlorophenyl isocyanate was diluted with Lutrol and administered, by intubation, to rats. The animals were given a volume equivalent to 0.5% of their body weight. Four groups of 5 males were given dose levels of 201, 342, 582 and 990 mg/kg and four groups of 5 females were given 41, 70, 118 and 201 mg/kg.

Result

LD50(male) = 402 mg/kg bw; LD50(female) = 91 mg/kg bw