3,4-dichlorophenyl isocyanate

GHS

General Information

Name:

1272/2008 CLP Henkel Registration (AOT 3, H301; AIT 2, H330; Skin Sens. 1A, H317; Eye Dam. 1, H318; Resp. Sens 1, H334; STOT SE3, H335; H400 Ma=1; H410 Mc=10); SPEC; AM <= 100%

Implementation:

EU

Remarks:

HENKEL REGISTERED SUBSTANCE

 

CS 157799; SPEC -

Data Tox, Reference:

- C&L based on study results;

- Resp. sensitisation based on EJ (ASS 1800110 -1):

The unique feature common to all isocyanates is that they contain N=C=O (isocyanate) functional groups attached to an aromatic or aliphatic parent compound. Isocyanates can cause skin sensitization, asthma, skin or mucous membrane irritation, and, rarely hypersensitivity pneumonitis. However, the most common adverse health outcome associated with isocyanate exposure is asthma due to sensitization.

 

Evidence exists that respiratory sensitization is triggered by dermal induction. In addition, vice versa, topical contact hypersensitivity was observed after previous induction by inhalation. The Technical Guidance Document (TGD) on information requirements for REACH (R.7a; page 256ff) proposes that, in the absence of specific health effects data, only diisocyanates that also meet the criteria for classification for skin sensitization are presumed to be respiratory sensitizers. It is assumed that this recommendation also applies to monoisocyanates such as 3,4-dichlorophenyl isocyanate. 3,4-Dichlorophenyl isocyanate is a strong skin sensitizer in the Magnusson & Kligman Test. It is therefore concluded that 3,4-dichlorophenyl isocyanate is contributing to the development of isocyanate asthma, presumably by inducing systemic sensitization.

 

According to the recent background document to the opinion on the Annex XV dossier proposing restrictions on diisocyanates (https://echa.europa.eu/documents/10162/ddc6108d-a33e-3087-6a6a-8754783c2aa8) RAC considers that for monoisocyanates, based on indirect evidence from humans and animals referenced in that document, the risk of respiratory sensitization in humans cannot be excluded.

 

The German Commission for Investigation of Health Hazards of Chemical Compounds in the Work Area also concluded (see p. 201:https://onlinelibrary.wiley.com/doi/pdf/10.1002/9783527812127.ch4) that sensitizing effects of monoisocyanates on the respiratory tract cannot be ruled out. However, data for the diisocyanates, which are assessed as potent respiratory allergens, would not justify classifying monoisocyanates as substances causing airway sensitization solely in analogy; an evaluation of the individual case is necessary.

 

Information on the individual structural analogues phenyl isocyanate (CAS 103-71-9) and 4-chlorophenyl isocyanate (CAS 104-12-1) support the conclusion that 3,4-dichlorophenyl isocyanate may pose a respiratory health hazard. Workers exposed to phenyl isocyanate showed specific IgE for isocyanate-albumin conjugates. These workers also developed asthmatic symptoms (BG Chemie, Phenylisocyanate Nr. 198, 1997). Furthermore, phenyl isocyanate is classified by German Commission for Investigation of Health Hazards of Chemical Compounds in the Work Area as respiratory sensitizer. 4-Chlorophenyl isocyanate, a close analogue to 3,4-dichlorophenyl isocyanate, is not skin-sensitizing when tested in a split adjuvant test in guinea pigs. However, 4-chlorophenyl isocyanate is classified as respiratory sensitizer according to CLP, Annex VI.

 

Taking all available information into account 3,4-dichlorophenyl isocyanate is classified as respiratory sensitizer in a Weight of Evidence assessment.

Data Eco, Reference:

The environmental classification is based on ecotoxicity data for the hydrolysis product 3,4 -Dichlorophenylamine against freshwater invertebrates. 

Related composition

Related composition:

3,4-Dichlorophenyl isocyanate

3,4-Dichlorophenyl isocyanate

Classification

Physical hazards

Explosives

Reason for no classification:

data conclusive but not sufficient for classification

Flammable gases and chemically unstable gases

Reason for no classification:

data lacking

Aerosols

Reason for no classification:

data lacking

Reason for no classification:

hazard class not assessed

Oxidising gases

Reason for no classification:

data lacking

Gases under pressure

Reason for no classification:

data lacking

Flammable liquids

Reason for no classification:

data lacking

Flammable solids

Reason for no classification:

data conclusive but not sufficient for classification

Self-reactive substances and mixtures

Reason for no classification:

data lacking

Pyrophoric liquids

Reason for no classification:

data lacking

Pyrophoric solids

Reason for no classification:

data conclusive but not sufficient for classification

Self-heating substances and mixtures

Reason for no classification:

data lacking

Substances and mixtures which in contact with water emit flammable gases

Reason for no classification:

data conclusive but not sufficient for classification

Oxidising liquids

Reason for no classification:

data lacking

Oxidising solids

Reason for no classification:

data conclusive but not sufficient for classification

Organic peroxides

Reason for no classification:

data lacking

Corrosive to metals

Reason for no classification:

data lacking

Desensitized explosives

Reason for no classification:

data lacking

Health hazards

Acute toxicity - oral

Hazard category:

Acute Tox. 3

Hazard statement:

H301: Toxic if swallowed.

Acute toxicity - dermal

Reason for no classification:

data lacking

Acute toxicity - inhalation

Hazard category:

Acute Tox. 2

Hazard statement:

H330: Fatal if inhaled.

Skin corrosion / irritation

Reason for no classification:

data conclusive but not sufficient for classification

Serious eye damage / eye irritation

Hazard category:

Eye Damage 1

Hazard statement:

H318: Causes serious eye damage.

Respiratory sensitisation

Hazard category:

Resp. Sens. 1

Hazard statement:

H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled.

Skin sensitisation

Hazard category:

Skin Sens. 1A

Hazard statement:

H317: May cause an allergic skin reaction.

Aspiration hazard

Reason for no classification:

data lacking

Reproductive toxicity

Reason for no classification:

data lacking

Effects on or via lactation

Reason for no classification:

data lacking

Germ cell mutagenicity

Reason for no classification:

data conclusive but not sufficient for classification

Carcinogenicity

Reason for no classification:

data lacking

1. Specific target organ toxicity - single (STOT-SE)

Hazard category:

STOT Single Exp. 3

Hazard statement:

H335: May cause respiratory irritation.

Affected organs:

other: resp. tract

Route of exposure:

inhalation

1. Specific target organ toxicity - repeated (STOT-RE)

Reason for no classification:

data lacking

Environmental hazards

Hazardous to the aquatic environment (acute / short-term)

Hazard category:

Aquatic Acute 1

Hazard statement:

H400: Very toxic to aquatic life.

Hazardous to the aquatic environment (long-term)

Hazard category:

Aquatic Chronic 1

Hazard statement:

H410: Very toxic to aquatic life with long lasting effects.

M-Factor acute:

1

M-Factor chronic:

10

Hazardous to the ozone layer

Reason for no classification:

data lacking

Labelling

Signal word:

Danger

Hazard pictogram

GHS09: environment

GHS05: corrosion

GHS06: skull and crossbones

Hazard statements

H400: Very toxic to aquatic life.

H410: Very toxic to aquatic life with long lasting effects.

H301: Toxic if swallowed.

H317: May cause an allergic skin reaction.

H318: Causes serious eye damage.

H330: Fatal if inhaled.

H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled.

H335: May cause respiratory irritation.