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EC number: 246-768-2 | CAS number: 25264-93-1
In a dermal sensitisation study using Neodene 6 alpha olefin in ethanol, Duncan Hartley guinea pigs (5 animals/sex/dose) were tested using a patch sensitisation method. For the three weekly initiating doses, a 1% solution Neodene 6 alpha olefin in ethanol was applied and the primary challenge dose was also 1% Neodene 6 alpha olefin in ethanol. Preliminary tests indicate that the 1% concentration was appropriate for the challenge dose, but a dose causing mild irritation should have been chosen for the initiating dose. Reactions were scored with a numerical grade to indicate severity. The positive control provided the appropriate response. Body weight gain was not affected by treatment. Neodene 6 alpha olefin caused little or no irritation after the initiation or challenge dose and did not induce a delayed contact hypersensitivity reaction under the conditions of the study.
This study received a Klimisch score of 2 and is classified as reliable with restrictions because although the study does not meet current OECD 406 guidelines, the study was well conducted and reported.
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