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EC number: 611-044-0 | CAS number: 53784-84-2
Assessment of acute oral toxicity of Broomdex in the rat (Acute Toxic Class Method) was performed according to OECD/EC guideline and in compliance with GLP principles. Broomdex was administered by oral gavage to two subsequent groups of three female Wistar rats at 2000 mg/kg body weight. No mortality occurred. Hunched posture and/or piloerection was noted for four animals on days 1 and/or 2. The body weight gain shown by the animals over the study period was considered to be similar to that expected for normal untreated animals of the same age and strain. No abnormalities were found at macroscopic post mortem examination of the animals. The oral LD50 value of Broomdex in Wistar rats was established to exceed 2000 mg/kg body weight. According to the OECD 423 test guideline, the LD50 cut-off value was considered to exceed 5000 mg/kg body weight. Based on these results, Broomdex is not classified according to Regulation (EC) No 1272/2008 and has no obligatory labelling requirement for acute oral toxicity.
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