Registration Dossier
Registration Dossier
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EC number: 412-570-1 | CAS number: 119462-56-5
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
In the GPMT following the 2nd (topical) induction 7 days after the intradermal induction, severe local effects were observed which would not be expected based on the response in the primary irritation test. As such, it may be assumed that the 2nd induction already had induced an allergic reaction, which is supported by the severe skin reactions seen after the challenge application. This means that Perkalink is a strong sensitiser, with the possibility that sensitisation reactions can occur following a single induction.
Migrated from Short description of key information:
In a GPMT test Perkalink tested positive in 19/20 animals; only 1/20 controls also showed a positive reaction.
Respiratory sensitisation
Endpoint conclusion
- Additional information:
See above.
Migrated from Short description of key information:
No data available; however, because of skin sensitising properties Perkalink 900 should not be inhaled.
Justification for classification or non-classification
Because of skin sensitising properties Perkalink 900 should be classified with R43 according to DSD-DPD; according to GHS-CLP this would be................
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