Registration Dossier
Registration Dossier
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EC number: 238-484-2 | CAS number: 14484-64-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

PBT assessment
Administrative data
PBT assessment: overall result
- PBT status:
- the substance is not PBT / vPvB
- Justification:
Data for the definitive conclusion on the PBT or vPvB properties of Ferbam (CAS No. 144484-64-1) are available.
Persistence (P):
According to the criteria stated in Regulation (EC) 1907/2006, Annex XIII, persistence can be determined through the evaluation of the dissipation half-lives of a substance in different environmental compartments. Experimental data on the biodegradation of Ferbam in water and soil (aerob, anaerob) are available. Hydrolysis (half-lives of 7.8 minutes, 12.1 minutes and not determinable because degraded instantly at pH 5, 7 and 9) and photolysis data in water contribute significantly to the degradation of this substance in water. Ferbam is also rapidly degraded in soil systems, in which half-lives below 30 days were reported, respectively. Thus, the P criterion is not met for this substance.
Bioaccumulation (B):
Experimental data determining the Bio Concentration Factor (BCF) of Ferbam in aquatic organisms are not available. Nevertheless, the log Kow of the substance is considered as a good surrogate for the evaluation of the B criterion. Based on its log Kow value, below 3, Ferbam shows low potential for bioaccumulation. Therefore, this substance does not meet the B criterion.
Toxicity (T):
According to the criteria stated in Regulation (EC) 1907/2006, Annex XIII, the toxicity of a certain substance can be assessed based on the available toxicity data on aquatic organisms and mammals. The long-term study performed testing the chronic effects of Ferbam on fish species resulted in a NOEC value of 100 µg a.i./L (above 0.01 mg/L). However, this substance is classified as Skin Irrit. 2 - H315; Eye Irrit. 2 - H319; STOT SE 3 - H335; Aquatic Acute 1 - H400; Aquatic Chronic 1 - H410; Acute Tox. 2 - H330 and Skin Sens. 1 - H317 and therefore it can be considered as T.
Reference
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