Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-653-4 | CAS number: 123-81-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- The acute toxicity study with the substance will be used to fill data gaps for acute toxicity endpoint. Furthermore, this information will strengthen the planned read-across approach by providing information about acute toxic effects of the substance.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 021
- Report date:
- 2021
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Limit test:
- no
Test material
- Reference substance name:
- Ethylene di(S-thioacetate)
- EC Number:
- 204-653-4
- EC Name:
- Ethylene di(S-thioacetate)
- Cas Number:
- 123-81-9
- Molecular formula:
- C6H10O4S2
- IUPAC Name:
- ethane-1,2-diyl bis(sulfanylacetate)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- ANIMALS
- Source: ENVIGO Ctra. St. Miquel del Fai, Km. 3 08182 - Sant Feliu de Codines Barcelona – Spain
- Age: 7 at arrival, 8-12 weeks on administrations
- Acclimatization: 5 days
- weight: approx. 180g
- Housing: 6 (before distribution) and 3 (after distribution)
- Diet: ad libitum Global diet 2914C; Envigo RMS Spain
- Water: ad libitum tap water
CONDITIONS:
- Light cycle: 12:12 – 07.00h to 19.00h CET
- Temperature: 22 ± 3 ºC
- Relative humidity: 30 – 70%
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- ethanol
- Remarks:
- purity: 96%
- Details on oral exposure:
- Animals will be fasted overnight before administration and approx. 3-4h afterwards
- Doses:
- 300, 50mg/kg bw
- No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- Clinical observations:
Approx. 30 minutes, 2h, and 4h post-administration daily thereafter for
14 days.
Body weight:
Once on acclimatisation week; On first day before administration, weekly thereafter and prior to sacrifice
Terminal investigation:
Animals will be sacrificed 14 days after administration (dose step 1; study day 15) and a gross necropsy will
be performed on all animals, including early deaths, if possible.
Animals will be will be euthanized in a CO2 atmosphere and subjected to a gross necropsy consisting in the
examination of the abdominal and thoracic cavities and contents. Any organ with gross lesions will be collected
and preserved in fixation medium (neutral-buffered 4 % formaldehyde) for histological evaluation, if considered
relevant (at additional costs). The organs will be temporarily stored for up to one month and will be discarded
if no microscopic examination is ordered by the sponsor.
Animals dying during the study or sacrificed for animal welfare reasons will be also subjected to a gross
necropsy. - Statistics:
- None
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- >= 50 - <= 300 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other:
- Mortality:
- In this acute oral toxicity study with the test item Thiocure it was seen that at doses of 300 mg/kg the test item caused immobility, lethargy, marked piloerection and respiratory difficulties, so for animal welfare decision animals were sacrificed. Therefore the mortality rate for 300mg/kg bw was determined to be 100%
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- The LD50 is between 50 and 300 mg/kg in rat after a single oral administration in both sexes.
- Executive summary:
The test substance Thiocure 120 was tested in an acute oral toxicity study using 3 female rats per dose group, at doses of 300mg/kg bw and 50 mg/kg bw. It was seen that at doses of 300 mg/kg the test item caused immobility, lethargy, marked piloerection and respiratory difficulties, so for animal welfare decision animals were sacrificed. At doses of 50 mg/kg bw rats showed no clinical signs and no mortality was observed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.