Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 256-589-1 | CAS number: 50448-95-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- This selected scenario covers the category approach for which the read-across hypothesis is based on structural similarity. For the REACH information requirement under consideration, the property investigated in studies conducted with different source substances is used to predict the property that would be observed in a study with the target substance if it were to be conducted. Similar properties are observed for the different source substances; this may include absence of effects for every member of the category.
There are expected to be differences in strength of the effects forming a regular pattern. The prediction will be based on a worst-case approach or trend analysis as appropriate for the respective endpoint. The read-across is a category approach based on the hypothesis that the substances in this category share structural similarities with common functional groups. This approach serves to use existing data on aquatic toxicity for substances in this category.
The hypothesis corresponds to Scenario 4 of the RAAF. The substances MMP, BuMP, EHMP, iOMP, iC13MP, ODMP, GDMP, TMPMP, PETMP, and Di-PETMP are esters of a common acid, 3-mercaptopropionic acid (3-MPA). The key functionality and main driver for ecotoxicity of the substances within this category is the presence of free SH-groups. It can be predicted with high confidence that the substances within this category will lead to the same type of effects.
For details, please refer to the category document attached to Iuclid section 13. - Reason / purpose for cross-reference:
- read-across: supporting information
- Reason / purpose for cross-reference:
- read-across source
- Test organisms (species):
- Daphnia magna
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 0.44 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Conclusions:
- Based on read-across, the 48 h EC50 of EHMP to Daphnia is 0.44 mg/L (nominal).
Reference
Description of key information
The toxicity of EHMP to Daphnia magna was estimated by read-across from other mercaptoacetates. The estimated EC50 is 0.44 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- EC50
- Effect concentration:
- 0.44 mg/L
Additional information
No experimental data are available for the target substance EHMP. A short-term toxicity study in Daphnia magna was conducted with the source substance iOMP. A justification for read-across is attached to Iuclid section 13.
A study was performed to assess the acute toxicity of the test material iOMP to Daphnia magna in accordance with OECD TG 202.
Pre-study solubility work conducted indicated that it was not possible to obtain a testable solution of the test material using traditional methods of preparation e.g. ultrasonication. The highest dissolved test material concentration that could be prepared (by visual examination) was
0.80 mg/l using a preliminary solution in tetrahydrofuran.
A pre-study media preparation trial indicated that a dissolved test material concentration of approximately 6.8 mg/l was obtained from a saturated solution method of preparation indicating this to be the limit of water solubility of this material under test conditions.
Following preliminary range-finding tests, twenty daphnids (2 replicates of 10 animals) were exposed to an aqueous solution of the test material at concentrations of 0.0068, 0.012, 0.022, 0.038, 0.068, 0.12, 0.22, 0.38 and 0.68 mg/l for 48 hours at a temperature of approximately 20°C under semi-static test conditions. The number of immobilised Daphnia were recorded after 24 and 48 hours.
A positive control conducted approximately every six months used potassium dichromate as the reference material. Daphnia magna was exposed to an aqueous solution of the reference material at concentrations of 0.32, 0.56, 1.0, 1.8 and 3.2 mg/l for 48 hours at a temperature of approximately 20°C under static test conditions. Immobilisation and any adverse reactions to exposure were recorded after 3, 24 and 48 hours.
Analysis of the saturated solution at 0 and 24 hours showed measured concentrations of 5.83 and 8.24 mg/l respectively.
Analysis of the freshly prepared media at 0 and 24 hours showed measured concentrations to range from less than the limit of quantitation (LOQ) to 0.811 mg/l. Analysis of the old media at 24 and 48 hours showed measured test concentrations to range from less than the limit of quantitation (LOQ) to 0.437 mg/l. This decline in measured concentration was in-line with the stability analysis which showed the test material to be unstable in the test medium.
The time-weighted mean measured test concentrations were calculated to be: 0.0068, 0.0032, 0.011, 0.017, 0.038, 0.076, 0.14, 0.26 and 0.49 mg/i. The 48-Hour EC50 for the test material to Daphnia magna based on time-weighted mean measured test concentrations was 0.31 mg/l with 95% confidence limits of 0.13 - 13 mg/l.
These values don't represent the real environmental conditions because the test substance is rapidly oxidized by the oxygen content in the aqueous phase. As the transformation products are less toxic than the parent substances (no free –SH groups) regulatory endpoints calculated on the basis of nominal concentrations represent a realistic worst case approach.
The 48 hEC50 was determined to be 0.44 mg/L based on nominal concentrations.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.