Registration Dossier
Registration Dossier
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EC number: 607-239-5 | CAS number: 23495-64-9
Endpoint summary
Administrative data
Description of key information
Oral:
The oral LD50 value of the test item in Wistar rat was established to exceed 2000 mg/kg bw.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- 1
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Oral:
One in vivo test is available in complied with OECD No.423. The test item was administered by oral gavage to two consecutive groups of three female Wistar rats at 2000 mg/kg body weight.
No mortality occurred.
Hunched posture, piloerection and/or salivation were noted for all animals on Day 1.
The body weight gain shown by the animals over the study period was considered to be normal.
No abnormalities were found at macroscopic post mortem examination of the animals.
The oral LD50 value of test item in Wistar rats was established to exceed 2000 mg/kg body weight, the LD50 cut-off value was considered to exceed 5000 mg/kg body weight.
Justification for classification or non-classification
Oral LD50: >2000 mg/kg bw
Therefore in accordance with Regulation (EC) No. 1272/2008 (amended by 286/2011) Table 3.1.1, this substance should not be classified for this endpoint.
Specific target organ toxicity-single exposure:
No significant non-lethal toxic effects observed in acute oral toxicity study.
Therefore in accordance with Regulation (EC) No. 1272/2008 Table 3.8.1, this substance should not be classified for this endpoint.
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