Registration Dossier

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
test procedure in accordance with national standard methods with acceptable restrictions

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1970
Report date:
1970
Reference Type:
study report
Title:
Unnamed
Year:
1970
Report date:
1970

Materials and methods

Principles of method if other than guideline:
LD50 in male mice after i.p. injection
GLP compliance:
no
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
N-methylacetamide
EC Number:
201-182-6
EC Name:
N-methylacetamide
Cas Number:
79-16-3
Molecular formula:
C3H7NO
IUPAC Name:
N-methylacetamide
Details on test material:
no further data

Test animals

Species:
mouse
Strain:
not specified
Sex:
male/female

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
water
Doses:
200, 1600, 3200, 4000, 5000, 6400 mg/kg bw
No. of animals per sex per dose:
5
Control animals:
no

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
3 500 mg/kg bw
Remarks on result:
other: for males and females combined

Any other information on results incl. tables

Mice died within 7 days.

Clinical signs: increased respiration rate, staggered gait, mice crouched down, dyspnoe, ruffled coat, prone position.

No clinical effects after 7 days.

Necropsy: suspicion for fatty liver at >=4000 mg/kg bw

Applicant's summary and conclusion

Conclusions:
LD50 in male & female mice after i.p. injection was 3500 mg/kg bw.
Executive summary:

LD50 in male & female mice after i.p. injection was 3500 mg/kg bw.