Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
July - August 1996
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1996
Report Date:
1998

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient - HPLC Method)
Version / remarks:
EU Method A.8
Deviations:
no
GLP compliance:
yes
Type of method:
HPLC method
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: crystalline
Details on test material:
PCMX
off-white, crystalline solid
Specific details on test material used for the study:
PCMX

Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficient
Key result
Type:
log Pow
Partition coefficient:
2.8
Temp.:
20 °C
pH:
6.1
Details on results:
The partition coefficient of PCMX has been determined to be 656, Log10 Pow "" 2.8.

Any other information on results incl. tables

The retention times, capacity factors and Log10 Pow values determined for the

sample are shown

Injection       Retention time (mins)       Capacity factor (k)       Log10 k       Log10 Pow

1                     7.894                                   1.91                     0.281              2.82

2                     7.887                                   1.91                     0.281              2.82

Applicant's summary and conclusion

Conclusions:
The partition coefficient of PCMX has been determined to be 656, Log10 Pow "" 2.8.
Executive summary:

Substances having a Log10 Pow greater than 3 are regarded as having the potential to

bioaccumulate in the environment.