Cholest-5-en-3-β-yl acetate

Surface tension

Administrative data

Endpoint:

surface tension

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because water solubility is below 1 mg/L at 20°C

Cross-reference

Reason / purpose for cross-reference:

data waiving: supporting information

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

from 08 Mar 2018 to 25 Mar 2018

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Reason / purpose for cross-reference:

reference to other study

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Version / remarks:

2016

Deviations:

no

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Version / remarks:

1995

Deviations:

no

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7840 (Water Solubility)

Version / remarks:

1998

Deviations:

no

GLP compliance:

yes

Type of method:

column elution method

Key result

Water solubility:

< 0.001 mg/L

Temp.:

20 °C

pH:

7.2

Remarks on result:

not determinable

Details on results:

No test item was detected at either flow rate.

Conclusions:

The water solubility of the substance at 20°C was determined to be <0.0011 mg/L.

Executive summary:

The water solubility of the substance was determined using the column elution method in a GLP study according to EC A.6, OECD 105 and OPPTS 830.7840.

Five samples were analysed at two flowrates (24 and 12 ml/h). Analysis was performed by a validated GC-FID method. No test item was detected at either flow rate. The water solubility of the substance at 20°C was determined to be below the linit of detection, i.e. <0.0011 mg/L. The pH of the water samples was 7.2.