Registration Dossier
Registration Dossier
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EC number: 222-774-0 | CAS number: 3608-67-1
Guidance on Safe Use
Administrative data
First-aid measures
- Most important symptoms and effects (both acute and delayed): can be described as atropine - like.
Symptoms are:
1. Dryness of the mouth and thirst
2. Disorders of accommodation (mydriasis) with impaired reactivity and inability to drive
3. Headache, difficulty in swallowing, speech disorders, restlessness
4. Tachycardia, drop in blood pressure, vertigo, apathy, hallucinations, unconsciousness
- General advice: Due to the atropine - like behaviour of the substance treat the person in the same way as if he/she were poisoned by atropine. Use physostigmine (effective in persons with peripheral and central symptoms), neostigmin, pyridostigmin or similar as antidot. If eyes are contaminated: rinse immediately and use pilocarpine eye drops.
Slight intoxications (no. 1 and 2) will disappear by themselves within 1-2 days. Remove affected person from the danger area and lay down. Remove all contaminated clothing and clean it mechanically. Get medical advise / attention if you feel unwell. In case of severse intoxication, take the affected person to fresh air. Seek medical advice.
- Following inhalation: drink plenty of water. Call a poison center or doctor / physician immediately if you feel unwell.
- Following skin contact: brush off loose particles and wash immediately with plenty of water and soap.
- Following eye contact: rinse immediately with plenty of water. Remove contact lenses if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice / attention.
- Following ingestion: rinse mouth with water (only if the person is concious). Induce vomiting if the person is concious. Call a poison center / physician if you feel unwell.
Fire-fighting measures
- Suitable extinguishing media:
water spray, dry powder, foam, carbon dioxide
- Unsuitable extinguishing media: water jet
- Special hazards arising from the substance or mixture:
formation of soot particles and / or toxic / corrosive vapours / gases (nitrous oxide, carbon dioxide, carbon dioxide) is possible
- Advice for fire fighter: wear a self-contained respirator and full protection suit. Collect contaminated extinguishing water separately. Don't let enter drains. Dispose residues and extinguishing water as hazardous waste in accordance with local / national / international regulations.
Accidental release measures
- Personal precautions:
Avoid contact with eyes, skin and clothing. Avoid dust formation and inhalation. Keep unprotected persons away from the substance.
- Protective equipment and emergency procedures:
Full face mask EN136 or filtering half-face mask EN140 or at least a filtering face piece EN149, protective gloves according to EN420 or EN374 (e.g. neoprene, nitrile- or butyl-rubber), protective suit.
- Environmental precautions:
Avoid release to the environment, do not allow to enter drains.
- Methods and material for containment and cleaning up: Tkae up the substance mechanically or use vacuum or moisten the substance with organic solvents (1-Propanol; Ethanol; Acetone) and / or use a binding agent. Place the substance and waste in appropriate containers for disposal. Dispose of this material / waste and its containers as hazardous waste.
Handling and storage
- Precautions for safe handling:
Keep container closed. handle in closed systems. Avoid dust formation. Provide suitable ventilation. Take precautionary measures against electrostatic discharges. Avoid contact with eyes, skin and clothing. Wash hands immediately with water and soap after using the product. Contaminated work clothing should not be allowed outside the workplace. Wash contaminated clothing before reuse. Avoid release to the environment.
- Conditions for safe storage, including any incompatibilities: Keep in original container. Keep container closed. Protect against contact with oxidizing agents, acids and bases. Store at room temperature. Take measure to prevent electrostatic discharges, keep awasy from sources of ignition. Store as combustible solid, e.g. according to German rules for joint storage of hazardous substances (TRGS510): storage class 13 (non-flammable solids).
Transport information
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Marine transport (UN RTDG/IMDG)
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Exposure controls / personal protection
To date, no national / international occupational exposure limits (DNEL) or hints on limits exist for this substance.
The production specification (procedures of manufacture) and the equipment (rigorous system contained) are documented in a management system. Personnel is trained, tested and supervised. PPE for workers use is specified in standard operating procedures (Betriebsanweisung) when there may be a potential of exposure e.g. during charging of the vessel, sampling, discharging at the end of the reaction etc.
- hand protection: protective gloves according to EN 374 made of nitrile-rubber (e.g. KCL 740 Dermatril (R)).
- body / feet protection: wear disposable protective overal type 4 (DIN EN 14605) or type 5 (DIN EN ISO 13982-1).
- eye / face / respiratory protetion: wear full face mask (EN 136) or filtering half face mask (EN 140) or in laboratory use / handling / analytical determination filtering face piece (EN 149). Wear alternatively eye or face protection / face protective shield according to EN 166, EN 170.
Stability and reactivity
The solid substance is chemically stable at room temperature for several years. Reactions are possible in contact with oxidizing agents, acids and bases, preferably in solution. As a solid such reactions are unlikely.
There are no hazardous reaction products at proper storage and use. Decomposition is possible above melting point and at >200 °C.
Disposal considerations
The substance is a hazardous waste according to EU 2014/955 (07 05 13 [solid wastes containing hazardous substances] or 07 05 14 [solid wastes other than those mentioned in 07 05 13]). Waste and contaminated packaging must be handled in accordance witj local regulations. Contaminated bags / contaminated secondary packaging or contaminated PPE should be disposed of like the substance itself or alternatively according to EU 2014/955 (15 01 10* [packaging containing residues of or contaminated by hazardous substances]).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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