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EC number: 203-674-6 | CAS number: 109-46-6
The following remarks on the toxicokinetics of DBTU are based on the available studies. Experimental toxicokinetic studies were not available. However, as per REACH guidance document R7.C (2014), information on absorption, distribution, metabolism and excretion may be deduced from the physical-chemical properties, including:
-Molecular weight: 188 g/mol
-Water solubility: 0.212 g/L (20°C)
-Partition coefficient Log Kow: 2.75
The physical-chemical characteristics of DBTU (log Kow 2.75) and the molecular mass (188 g/mol) are in the range suggestive of absorption from the gastro-intestinal tract subsequent to oral ingestion (with a molecular weight below 500, and a log Kow between -1 and 4). This assumption of an oral absorption is confirmed by the acute oral toxicity study in which mortalities were observed at the dose of 2000 mg/kg bw.
Molecular weight (near to 200 g/mol) is in ranges which favour dermal absorption. This assumption of a dermal absorption is confirmed by the skin sensitisation data as DBTU is a skin sensitizer.
DISTRIBUTION and METABOLISM
As a small molecule a wide distribution of DBTU is expected.
No specific information was found on metabolism of DBTU.
DBTU is probably excreted in the urine, because it is a water-soluble substance with a low molecular weight (below 300); and generally, they are conjugated metabolites from Phase II biotransformation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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