Registration Dossier

Administrative data

Endpoint:
additional toxicological information
Adequacy of study:
other information
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: 3c: Unsuitable test system.

Data source

Reference
Reference Type:
publication
Title:
Embryotoxicity of industrial chemicals on the chicken embryo: Thiourea derivatives
Author:
Korhonen A., Hemminki K, Vainio H.
Year:
1982
Bibliographic source:
Acta pharmacol. et toxicol., 1982; 51: 38-44.

Materials and methods

Type of study / information:
Type: other: in vitro test, on chicken embryo

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
TS-Freetext:
- Source: from the rubber factory of Oy Nokia Ab, Nokia, Finland.
- Batch number: no data
- Purity: no data

Results and discussion

Any other information on results incl. tables

PARAMETERS ASSESSED DURING STUDY:
- Test substance caused early deaths but no malformation and no late death.
- The number of early deaths increased with the concentration range:
. 0 % at 0.13 µmol/egg,
. almost 50 % at 0.25 µmol/egg,
. almost 75 % at 0.50 µmol/egg
. and around 100 % at 0.75 and 1.0 µmol/egg.

CALCULATED PARAMETERS:
ED50, total effect
= LD50, total mortality
= LD50, dead not malformed
= LD50 early deaths
= 0.28 µmol/egg (with 95 % confidence limits: 0.24-0.34 µmol/egg)

=> Strong embryotoxic (embryolethal)

Applicant's summary and conclusion